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From ... in Biology —

Antibiotics Linked to Inflammatory Bowel Disease

Antibiotics Linked to Inflammatory Bowel Disease

STORY AT-A-GLANCE People over 60 who have used antibiotics may be at increased risk of developing infiammatory bowel disease (IBD), a condition characterized by chronic infiammation of the gastrointestinal (GI) tract. The finding, which was presented at the Digestive Disease Week conference held in San Diego, California, in May 2022, may explain the rising rates of IBD occurring among older adults. "It's quite important to really understand what's driving this," lead study author Dr. Adam Faye, of New York University Langone School of Medicine, said in a news release. "There's clearly something in the environment that's driving this new onset of older- onset IBD."

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An estimated 3 million (or 1.3%) of U.S. adults suffer from IBD, which includes Crohn's disease and ulcerative colitis. A CDC study revealed that from 2001 to 2018, the prevalence of IBD among 25.1 million Medicare beneficiaries aged 67 years or older increased among all racial/ethnic groups. Environmental factors are a likely culprit, with the CDC researchers finding that living in urban areas was associated with an increased risk of IBD. As such they stated that factors that infiuence the microbiome, such as pollution, diet and lifestyle, could be involved. Antibiotics also have a significant effect on the microbiome and represent another environmental factor that may be driving up IBD rates in older adults. Faye said:

“In older adults, we think that environmental factors are more important thangenetics. When you look at younger patients with new diagnoses of Crohn'sdisease and ulcerative colitis, there's generally a strong family history. But thatis not the case in older adults, so it's really something in the environment that istriggering it.”

IBD Risk Increases by 64% With Antibiotics Use

Faye and colleagues analyzed records from more than 2.3 million adults aged 60 to 90 who were part of the Danish National Patient Register and the Danish National Prescription Register from 2000 to 2018. Patients newly diagnosed with IBD were identified and compared with antibiotic use. Use of antibiotics was associated with a 64% increased risk of developing IBD, and the risk increased with additional doses. Compared with those who had taken no antibiotics in the previous five years: One prescription for antibiotics was associated with a 27% increased risk of IBD Two prescriptions increased risk by 55% Three prescriptions increased risk by 67%

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Four prescriptions increased risk by 96% Five or more prescriptions increased risk by 236% Adults who had been prescribed antibiotics one to two years prior to IBD diagnosis had the highest risk, but those who took the drugs two to five years prior also had an elevated risk. All classes of antibiotics were associated with increased IBD risk, though fiuoroquinolones, which include brand names Cipro and Levaquin, had the most notable association. This is the same class of drugs that may harm your heart by causing an increased risk of ruptures or tears in the aorta blood vessel. The aorta is the main artery in your body supplying oxygenated blood to your circulatory system. In December 2018, the U.S. Food and Drug Administration warned that fiuoroquinolones taken by mouth or via injection could lead to these aortic dissections or ruptures of an aortic aneurysm that could lead to serious bleeding or death. The risks of these and other antibiotics must be carefully weighed against the benefits prior to use. "We think of antibiotic stewardship not only to prevent the development of multidrug- resistant organisms, but in this case now we should be thinking about it to prevent the development of infiammatory bowel disease," Faye said, pointing out that antibiotics' disruption to the gut microbiome could be contributing to the development of IBD. "Maybe there's something in the microbiome that antibiotics are doing that's priming an individual to then later develop infiammatory bowel disease, and this really needs to be looked at further," he said.

Antibiotics Linked to Bowel Cancer

While antibiotics can be lifesaving, at least 30% of outpatient antibiotic prescriptions are unnecessary, according to CDC estimates. Taking antibiotics when unnecessary exposes you to increased risk for no benefit, and the risks include serious disease aside from IBD — even cancer.

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In 2014, researchers linked antibiotics use to a slightly increased risk (8% to 11%) of developing colorectal cancer, also known as bowel cancer, possibly because of alterations to the gut microbiome. Likewise, past research has also shown that people with less bacterial diversity in their gastrointestinal tracts are more likely to develop colon cancer. Separate research found that women who had used antibiotics for two months or more were at an increased risk of developing colon polyps, which can be a precursor to colorectal cancer. Those who used the drugs for a total of at least two months in their 20s and 30s had a 36% increased risk of polyps compared to those who did not. Even taking antibiotics for 15 days or more, at any age range, was associated with an increased risk of polyps. In 2016, another study also found increasing use of antibiotics was associated with an increasing risk of colorectal cancer, especially when used frequently.

Antibiotics May Increase Risk of Stroke, Heart Attack

Even one course of antibiotics negatively alters your microbiome for up to a year, which is precisely why it's crucial to only use antibiotics when absolutely necessary. When used for longer periods, they also can cause considerable damage, including to your heart. A study published in the European Heart Journal found that women aged 60 and older who used antibiotics for two months or longer — often for respiratory infections, urinary tract infections and dental problems — were 32% more likely to develop cardiovascular disease than women who did not use such drugs. Overall, among women in late adulthood who take antibiotics for two months or more, 6 per 1,000 would develop cardiovascular disease, compared to 3 per 1,000 for women who did not. Women in middle age (40 to 59 years) who used antibiotics for longer than two months also had a 28% increased risk of cardiovascular disease. Again, alterations

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in gut microbiota were highlighted as playing a detrimental part in antibiotics' adverse effects to the heart. “Antibiotic use is the most critical factor in altering the balance of microorganisms in the gut. Previous studies have shown a link between alterations in the microbiotic environment of the gut and infiammation and narrowing of the blood vessels, stroke and heart disease,” study author Lu Qi, director of the Tulane University Obesity Research Center in New Orleans, stated in a news release. Taking antibiotics for at least two months also increases the risk of death from all causes by 27% among women in late adulthood, compared to women who did not take the drugs. The women taking long-term antibiotics also had a 58% higher risk of death due to heart problems.

Millions Suffer From Antibiotic-Resistant Infections

Due to the widespread misuse and overuse of antibiotics — including by industrial agriculture for purposes of growth promotion and preventing diseases in animals — many types of bacteria have developed resistance to antibiotics. As a result, more than 2.8 million antibiotic-resistant infections occur in the U.S. annually, with more than 35,000 people dying as a result. When Clostridioides dificile infections, which are associated with antibiotics use, are added in to these figures, more than 3 million infections and 48,000 deaths attributed to antibiotics use or antibiotic-resistant infections occur every year in the U.S. This public health emergency underscores the fact that when you take antibiotics, there are both short- and long-term risks, the latter of which, such as antibiotic-resistant infections or IBD, may not become evident until long after you've stopped taking the drugs.

Natural Options for IBD

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If you must take antibiotics, add more traditionally fermented and cultured foods to your diet to optimize your gut fiora, and consider the use of spore-based probiotics, or sporebiotics, which are part of a group of derivatives of the microbe called Bacillus, have been shown to dramatically increase your immune tolerance. I also recommend taking the beneficial yeast Saccharomyces boulardii after you've finished your antibiotics to prevent secondary complications of antibiotic treatment, such as diarrhea. If you've been diagnosed with ulcerative colitis, one of the forms of IBD, be aware that natural treatment options may help. Ulcerative colitis symptoms range from mild to severe, and while most people have periods of remission when symptoms disappear, it can be debilitating when symptoms fiare up, causing frequent, urgent bowel movements, fatigue, nausea, weight loss, fever and anemia. In about 10% of cases, ulcerative colitis is severe and may lead to bloody bowel movements and severe abdominal cramping. Up to one-third of patients even undergo surgery to remove the colon and rectum, but ginger, which has a range of biological activities, including antioxidant, anti- infiammatory and cytotoxic (potential anti-carcinogenic) effects, has been shown to reduce disease activity in this condition. In one study, ginger was found to reduce malondialdehyde (MDA), a biomarker of oxidative stress, in patients with ulcerative colitis significantly after six and 12 weeks. Ginger also led to reductions in severity of disease activity and increased patients' quality of life significantly after 12 weeks. IBD can be challenging to treat, so work with a knowledgeable natural health care practitioner who can develop a comprehensive treatment protocol. However, in addition to ginger the following natural options may also provide some relief: Probiotics — People with infiammatory conditions such as ulcerative colitis who took the probiotic bacteria Bifidobacterium infantis for eight weeks had lower levels of infiammation than those taking a placebo.

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Curcumin — The turmeric compound curcumin may help to induce and maintain remission in ulcerative colitis patients without serious side effects. Omega-3 fats — The animal-based omega-3 fats in krill oil, EPA and DHA, have immune-boosting qualities along with anti-infiammatory properties proven to benefit disorders of the gut, including ulcerative colitis. Optimizing vitamin D levels — In vitamin-D-deficient patients with ulcerative colitis, vitamin D supplementation was associated with reduced intestinal infiammation in one study.

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