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From ... in Biology Health Research —

How a Bacterium Can Spread Abnormal Cell Growth

The diagnosis of cancer can trigger strong emotions of fear, anger, anxiety and sadness. The National Cancer Institute estimates 606,520 people will die from cancerin 2020, or 1,661 people each day.

How a Bacterium Can Spread Abnormal Cell Growth

They also estimate there will be 1,806,590 new cases diagnosed. That is an astounding 4,949 people who will receive a diagnosis of cancer every day in 2020.Breast, lung, prostate and colorectal are the most common types of cancers. In 2020, prostate, lung and colorectal cancers will account for an estimated 43% of all cancers in men.

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The three most diagnosed cancers in women are breast, lung and colorectal, which will total an estimated 50% of all new diagnoses. The worldwide statistics are just as overwhelming: In 2018, 18.1 million people learned they had cancer and 9.5 million diedfrom it. Experts expect these numbers to rise precipitously by 2040, when 29.5 millionwill learn they have cancer and 16.4 million will die of some form of the disease. Although many publications have stated that nearly 90% of deaths in people who die from cancer are from metastases, the leaders of one nation wide study found the percentage of metastatic deaths from solid tumors to be 66.7%.

One Bacteria May Be Implicated in Cancer Metastasis

In the past year, three separate research teams found that Fusobacterium nucleatumplays an unexpected and an active role in the metastasis of colon cancer. The first connection was discovered nearly nine years ago when researchers found the bacterium's DNA in colon tumor tissue. Since then, other scientists have found that an infection by this bacterium in tumor cells raises the risk of poor prognosis, resistance to chemotherapy and metastases incolorectal cancer. Chronologically, the first paper was published by a group of scientists working to assessthe function Fusobacterium nucleatum has on colorectal metastasis. They found anabundance of bacteria in tissue from patients with metastasis. Based on the data, they concluded that the bacteria orchestrates autophagy to controlmetastasis and that targeting it can be used to devise strategies to prevent and treatcolorectal metastases. In a second study, the researchers began with the understanding that the presence ofthe bacteria is associated with poor patient outcomes; however they sought to clarify whether it was involved in metastasis. The results from their animal study indicated that an infection of the tumor promoted migration within the body. Specifically, they found metastasis to the lungs induced by changes in genetic regulation.

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In a third laboratory study, doctors used cultured human colon tumor cells and found that when the bacteria invaded the colorectal cells it induced the secretion of proinfiammatory cytokines IL-8 and CXCL1. Both are associated with the promotion of cell migration, which is a step in metastasis. They concluded that the findings demonstrated a direct and indirect modulation of cell signaling and migration. The bacterium is supposed to help fight the cancer, but instead, it actually makes it worse. Biochemist Daniel Slade said it is "like throwing gas on an already lit fire". Microbiologists from Hebrew University reported some of the same findings from as tudy of breast tumors in which F. nucleatum was found in 30% of the tissue examined. Interestingly, it was most common in cancer cells with surface sugar molecules. The infection appears to promote growth and metastasis in animal models of breast cancer. Microbiologist Gilad Bachrach told a reporter from Scientific American that "The data imply that fusobacterium is not a cause of cancer, but it can accelerate progression."

An Ounce of Prevention

While the information about the role that bacteria and fungi play in the progression or metastasis of cancer is important, it is also crucial to remember that an ounce of prevention is always worth a pound of cure. Many of the small lifestyle choices we make each day have long-term effects on overall health. One of the preventive measures your physician may recommend is a colonoscopy as a screening tool for colorectal cancer. However, it's important to consider all the factors before undergoing the procedure, as it has certain risks, including possible contamination of the equipment used, depending on how the medical facility cleans it. There are also certain dangers in the procedure itself. A simple preventive measure you can begin at home without a prescription is optimizing your mitochondrial health. Since cancer is a metabolic disease and not a genetic one as

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I've thoroughly covered in past articles, when your mitochondria are healthy and functional your chances of getting cancer are greatly reduced. The traditionally held view has been that cancer is a genetic disease. However, the past work of Dr. Otto Warburg, who received the Nobel Prize in Physiology or Medicine in 1931 for the discovery of the metabolism of malignant cells, tells a different story. Herealized that cancer is triggered by a defect in cellular energy metabolism which occurs primarily in the mitochondria. In his time, mitochondria were not well understood. But scientists now have a better grasp of how these small powerhouses provide energy and function within the body. In 2016 we presented the Mercola.com Game Changer Award to Thomas Seyfried, Ph.D.,professor of biology at Boston College and a leading expert and researcher in the field of cancer metabolism and nutritional ketosis. As noted in one of my past articles, Seyfried said the problem is not that physicians and researchers don't understand the science behind the metabolic theory of cancer, it's that accepting it would change their approach to treatment.

Cancer Origin Would Change Treatment Strategies

If defective mitochondria are responsible for the observable characteristics of cancer,then how would the disease be treated? His compilation of research from independentand well-respected scientists within various disciplines was, in my view, one of hisbiggest contributions to this science.He put this work together to form a scientific foundation for the theory that cancer is ametabolic disease and not a genetic one. He believes that genetic mutations are adownstream effect of defective energy metabolism in the mitochondria and not thetrigger for the development of a cancerous growth.The idea that cancer is a genetic disease determines research funding for treatment andfuels the entire cancer industry. In 2018 Seyfried was interviewed by Dr. Peter Attia,who published the podcast on his site. In the interview, he provides details about the

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mechanics of cancer, why cancer cells grow and how conventional medicine may havegotten it wrong when it comes to treatment.Toward the end of the interview Seyfried shared suggestions for those considering cancer treatment, such as: Be careful to avoid biopsies if at all possible, as they are related to metastasis. Surgical therapy can be a useful, but it should be delayed as long as possible while metabolic therapy is being used, so the tumor will shrink and allow the margins to be more well defined, allowing it to be removed more easily. Avoid radiation and chemotherapy, as they typically impair the immune system that is ultimately responsible for resolving the tumor. It is vital to understand that more people die from cancer treatment than cancer itself. Seyfried recommends using a ketogenic diet to support mitochondrial health. The mechanism of action is clear with regard to attacking cancer cells. It is based on the pioneering findings of Warburg and the nature and action of cellular respiration.

How Metabolic Therapy May Help Prevent and Treat Cancers

Seyfried's research demonstrates that cancer growth and progression can be managed using whole body transformation from fermentable metabolites, such as glucose and glutamine, to respiratory metabolites, primarily ketone bodies that form when you follow a ketogenic diet. In an earlier article, I discussed Seyfried's research in which he found that the transition reduces tumor vascularity and infiammation while enhancing tumor cell death. The diet takes advantage of the fact that cancer cells prefer anaerobic (without oxygen) fermentation to derive energy, causing an overproduction of lactic acid. Although aerobic (using oxygen) respiration is more eficient, cancer cells behave differently than normal cells and continue to produce massive amounts of lactic acid,

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even in environments of 100% oxygen. This caused Warburg to conclude that the respiratory system in cancer cells is defective. In this case, the respiratory system does not refer to the lungs of an organism but rather how a cell processes oxygen. It is estimated that 5% to 10% of all cancers are caused by gene mutations, or an inherited genetic risk factor. BRCA1, which raises the risk for breast cancer and BRCA2, which raises the risk for ovarian cancer, are examples. However, Seyfried notes that these mutations do not guarantee you will develop cancer, unless it damages the mitochondrial respiratory system. The take-home message is that if your mitochondrial respiration remains healthy, your risk of cancer is relatively low. So, what lifestyle choices will help to keep your mitochondria healthy? Primarily, avoiding toxic environmental factors and implementing healthy lifestyle strategies will infiuence your mitochondrial health. This is the sole focus of metabolic mitochondrialtherapy described in my book “Fat for Fuel”. There are six strategies that top my list for helping optimize your mitochondrial health. They include cyclical nutritional ketosis, meal timing, normalizing iron levels andspecific nutritional supplements.

Restricting Glucose in Cancer Treatment Essential to Success

In 1971, U.S. President Richard Nixon declared war on cancer and signed the NationalCancer Act. The goal was to make a national commitment to find a cure. Since then,many chemotherapeutic and surgical treatments have been developed.Chemotherapy has been a primary treatment used in cancer alongside the surgicalresection of solid tumors. The objective of chemotherapy has been to destroy cancercells so they do not recur. However, chemo, which is technically a poison, travelsthrough the entire body and affects every cell.

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Seyfried recommends a strategic approach to address cancer by cleaning up themicroenvironment. In a 2017 article, Seyfried and colleagues outlined a therapeuticstrategy for the metabolic management of cancer. The strategy involves stimulatingcancer-specific oxidative stress in order to elevate ketone bodies that protect normalcells while causing apoptosis in the cancer cells.

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