From ... in Psychology — Sep 17, 2023

Microdosing Psilocybin: Everything You Need to Know

You’ve probably heard about microdosing by now, and maybe you’re considering trying it yourself.

You can microdose just about anything, but if you want to learn more about microdosing psilocybin, keep reading. In this guide, you’ll learn all about psilocybin mushrooms, how much is a microdose of shrooms, and why people choose to microdose. Plus, we’ll talk about some of the latest research on the benefits of microdosing mushrooms. Psilocybin mushrooms, also known as magic mushrooms, are psychoactive fungi.

There are dozens of strains of psychedelic mushrooms, and they can have varying potencies. Eating psilocybin mushrooms can lead to altered senses, such as enhanced colors and distorted visuals, to full-blown hallucinations in larger doses. When taken in larger quantities, the effects can include a confused sense of reality, loss of coordination, and ego death. However, in smaller quantities, like microdoses, psilocybin mushrooms offer subtle – yet profound – therapeutic effects for many people. It usually takes about 30 minutes to digest psilocybin mushrooms and feel the effects. However, keep in mind that a microdose of mushrooms should not produce noticeable effects. Instead, the effects are sub-perceptual.

They still work within your body, but you shouldn’t feel high or altered. Instead, people report an improved feeling of wellness or clarity. Some strains of mushrooms can provide an energizing boost. Most of the time, people eat dried mushrooms. When microdosing mushrooms, capsules, or portioned chocolates are an easy way to obtain consistent doses. All you have to do is grind up the dried mushrooms with a coffee grinder or high-performance blender until they become powdered. Using a capsule filling machine (or by hand), fill the capsules with the powdered mushrooms. You’ll need a small digital scale to tear the weight of the empty capsule so you can measure it against a filled capsule. This will help you keep the doses consistent for all caps. If you don’t want to go the capsule route but still want to microdose mushrooms, consider brewing a mushroom tea or simply eating them dried. Some people dislike the bitter taste and chewy texture, so adding them to other foods can be helpful. Some people have a hard time digesting mushrooms, and they can cause an upset stomach. To help combat this, you can try lemon tekking. This involves soaking the mushrooms in freshly squeezed lemon juice for ten minutes before eating them.

The strong acidity of the lemon juice breaks down the cell wall, speeding up the time it takes to turn psilocin into psilocybin. Not only does it lighten the digestive load, but it helps the mushrooms kick in faster. Typically, psilocybin doses are measured in grams.

The most common type of psilocybin mushroom is Psilocybe cubensis which contains approximately 0.6% psilocybin when dried. This means every gram of P. cubensis contains 6 mg of pure psilocybin. Although there is no universal standard on psilocybin mushroom dosage, there are some guidelines that can be helpful when learning how to microdose shrooms. Remember to go at your own pace, and if you are sensitive to other substances, you might also be sensitive to psilocybin.

The goal of microdosing mushrooms is not to get high, so less is often more in this case. So, how much is a microdose of shrooms? A mushroom microdose is considered somewhere between 0.1-0.2 grams. That’s one-tenth to one-twentieth of a gram. Although, to account for folks with a naturally lower or higher tolerance, it’s safe to say a microdose of psilocybin may be 0.05 to 0.25 grams. When first starting out, you might even want to start with 0.05 grams on the first day to make sure you don’t experience any uncomfortable effects. On your next dose, bump it up to 0.1, and see how you feel. This is a perfect dose for many people, yet others prefer more. Remember, the goal is to take a small yet substantial dose that doesn’t produce any physical side effects. If the walls start breathing, you’ve taken more than a microdose. Beyond a microdose, there are varying degrees of doses that all go by different names.

There is a mini dose, museum dose, moderate dose, mega dose, or macro dose. Sometimes referred to as a ‘heroic dose,’ a macro dose is five grams of mushrooms or more. Do not attempt to take this amount unless you are quite experienced with psilocybin and have a trip sitter with you the entire time. A macro dose is entirely the opposite of a micro dose, and your entire sense of self and the world around you may shift to an unrecognizable scene. Now, this might be incredible and breathtaking, or it may be extremely uncomfortable for many hours, resulting in a bad trip. Before you start a microdosing protocol, decide what kind of schedule you’d like to follow.

There is no one right way to microdose, but there are a few popular options. For example, taking your dose every third day is believed to prevent tolerance and provide the most long-term results. However, other proponents of microdosing suggest that there is no harm in taking a dose daily and pausing for 30 days after you’ve been microdosing for 90 days. The brass tacks of it is that there is still not enough conclusive evidence that suggests exactly how to microdose shrooms. It’s a personal matter and one that should be decided on an individual level. Maybe you’d like to take them for two days, then break for one. Or, perhaps you only want to dose every other day. Tap into your intuition and determine the best path for you. You might find it helpful to keep a diary of your schedule and monitor your results over time. Paul Stamets created a unique microdosing technique he calls “stacking.” It involves a combination of niacin, Lions Mane, and P. cubensis. This method combines approximately 0.1-1 gram of P. cubensis, 5-20 grams of Lions Mane, and 101-200 milligrams of niacin. His belief is the niacin enhances the effects of the psilocybin while reducing the psychedelic experience. Organizations like the John Hopkins Center for Psychedelic and Consciousness Research, and the Multidisciplinary Association for Psychedelic Studies (MAPS) are coming to similar conclusions in the early stages of their research. Psilocybin is gaining momentum as an option for patients with treatment-resistant depression.

There is also significant evidence that veterans and others with post-traumatic stress disorder may find relief from symptoms with psilocybin mushrooms. While these may be the cornerstone breakthroughs we’re looking for with psilocybin, there are plenty of other benefits that can improve our daily lives. Many people are finding relief from stress and anxiety and getting better sleep because their mind is less entrenched in circular, worrisome thoughts. Those microdosing mushrooms for a month or more report a greater ability to tackle complex problems. This is largely due to the enhanced creativity that lends a hand to divergent thinking. Overall, anecdotal evidence largely returns to the overall mood and outlook improvement after microdosing. Although the dosage is minimal, it’s enough to make you feel better. And with continued usage, others are reporting ongoing improvements across other avenues of their lives as well.

The future of microdosing psilocybin mushrooms is on the verge of massive impact. Although cultivation is illegal right now, It won’t be long before this medicine is available to a larger audience, and the stigma behind magical fungi will be a thing of the past. While individual experiences may vary, there are some commonly reported effects of microdosing psilocybin: It’s important to note that while these effects are commonly reported, individual responses can vary. Additionally, the legality and regulations surrounding psilocybin use vary by location, so it’s crucial to research and follow local laws and consult with a healthcare professional if you have any concerns or pre-existing medical conditions.

The psychedelic community strongly believes microdosing psilocybin should be further studied for its potential therapeutic benefits. A wide range of reports that exist including anecdotal reports of individuals regularly microdosing with psilocybin. One of these reports involved a person suffering from Bipolar II and PTSD looking for a solution to their seasonal depression. After trying a wide range of medications and therapies, they eventually tried microdosing psilocybin with a full understanding it could increase their levels of mania.

They found taking 0.2 grams every fourth day highly increased mania, so they cut back the regularity and dosage to 0.15 grams every other week. This new schedule helped them better manage their seasonal depression even going as far as stating, “it was the first winter I’ve ever had where I wasn’t depressed.” Another user suffering from depression reported that they “felt more capable, emotionally resilient, faster in mental/emotional recovery, and a much-improved ability to choose other actions.” Yet, some folks look to microdosing psilocybin to enhance creative and divergent thinking in their daily lives. “I find that microdosing mushrooms helps me think through my problems, instead of looking for ways to get around them,” says another user who likes to take 0.1 grams for three days on, four days off. One of the most important aspects of microdosing psilocybin is ensuring a consistent dosage. Dosage refers to the dose of the substance as well as the time-frequency and duration that the doses are taken. A microdose is such a small amount that it is easy to accidentally consume a larger dose than expected. Psilocybin mushrooms make this even more difficult due to the varying strengths of the different species and individual mushrooms. One example of this can be seen in the differences in potency between the cap and stem of psilocybin mushrooms. A study analyzing psilocybin mushrooms in Japan found that the P. cubensis had a maximum potency of 1.27% in the stem and 1.35% in the cap. This study also showed whole mushrooms had a potency ranging from 0.37% to 1.30%. Psilocybin is a serotonergic substance meaning it acts on the serotonin, or 5-hydroxytryptamine, receptors in the central and peripheral nervous system.

The primary receptors it acts upon are the 5-HT2B and 5-HT2C receptors. It also activates the 5-HT2A receptors with slightly lower activity.

The activity at these receptors causes an increased concentration of dopamine at the basal ganglia. This is responsible for the euphoric and psychedelic effects of psilocybin. Small doses of psilocybin, referred to as a “microdose,” do not produce any acute effects, but rather a psychological and social benefit from regularly consuming microdoses.

These effects include increases in: When consumed in large doses, psilocybin produces a profound psychedelic effect involving: Psilocybin, along with most other psychedelics, causes vasoconstriction. This means mixing it with other vasoconstrictors can cause unpleasant and potentially dangerous effects. Mixing psilocybin with any MAOIs can enhance its potency which could cause a microdose to produce stronger effects than expected. Alcohol mixed with psilocybin mushrooms can place unnecessary stress on the liver since they are both metabolized by it.

The primary safety concern with microdosing psilocybin is alterations in heart rate. Using psilocybin with a pre-existing heart condition can cause tachycardia or bradycardia. Psilocybin is a controlled substance in most of the modern world. In some places, they are classified as illegal substances, while in others, there are exceptions or decriminalization measures in effect. For instance, in some countries like Brazil, Jamaica, Portugal, and the Netherlands, psilocybin mushrooms are either decriminalized or tolerated to some extent. In these places, there might be legal loopholes, religious exemptions, or specific regulations allowing their use. In certain regions of the United States, such as Oregon and some cities like Denver, Colorado and Oakland and Santa Cruz in California, there have been initiatives to decriminalize or regulate the use of psilocybin. This often involves measures like allowing supervised medical use or making enforcement of psilocybin-related offenses a low priority. However, it’s crucial to remember that even in places where there have been reforms or decriminalization efforts, specific laws and regulations can be complex and subject to change. Always check your local and national laws, and if you have any uncertainties or legal concerns, it’s best to consult with a legal professional who is well-versed in your jurisdiction’s drug laws. A Foraging Trip: Where Do Magic Mushrooms Grow?Eager to learn more about the origin of psilocybin species? Read this article to find out where magic mushrooms grow and more! How to Make Shroom Tea: Best Recipe and DosageA step by step guide on how to brew shroom tea, and why entheogenic psilocybin tea is a preferred method for psychedelic connoisseurs. R. Gordon Wasson: Author and Mushroom ExpertLearn about R. Gordon Wasson, the “legendary mushroom expert” and popular figure within the psychonaut community. Shrooms vs Acid: Differences and Similarities ExplainedEver wondered what the differences are between shrooms vs acid, or if you can take both together? This guide explains what you need to know. Quantum Mechanics, Reality, and Magic MushroomsScientist and author Dr. Chris Becker takes an in-depth approach in understanding how we perceive reality through magic mushrooms and quantum mechanics. Psilocybin Guide: Effects, Common Uses, SafetyOur ultimate guide to Psilocybin has everything you want to know about this psychedelic fungi from its uses to its legal status.

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The measure received its official title and now needs signatures. Canada Approves Psilocybin Treatment for Terminally-Ill Cancer PatientsCanada’s Minister of Health, Patty Hajdu approved the use of psilocybin to help ease anxiety and depression of four terminal cancer patients. Mapping the DMT ExperienceWith only firsthand experiences to share, how can we fully map the DMT experience? Let’s explore what we know about this powerful psychedelic. Guide to Machine Elves and Other DMT EntitiesThis guide discusses machine elves, clockwork elves, and other common DMT entities that people experience during a DMT trip. Is the DMT Experience a Hallucination? What if the DMT realm was the real world, and our everyday lives were merely a game we had chosen to play? How to Store DMTNot sure how to store DMT? Read this piece to learn the best practices and elements of advice to keep your stuff fresh. What Does 5-MeO-DMT Show Us About Consciousness?How does our brain differentiate between what’s real and what’s not? Read to learn what can 5-MeO-DMT show us about consciousness. How to Smoke DMT: Processes ExplainedThere are many ways to smoke DMT and we’ve outlined some of the best processes to consider before embarking on your journey. How to Ground After DMTKnowing what to expect from a DMT comedown can help you integrate the experience to gain as much value as possible from your journey. How To Get DMTWhat kind of plants contain DMT? Are there other ways to access this psychedelic? Read on to learn more about how to get DMT. How DMT is Made: Everything You Need to KnowEver wonder how to make DMT? Read our guide to learn everything you need to know about the procedures of how DMT is made. Having Sex on DMT: What You Need to KnowHave you ever wondered about sex on DMT? Learn how the God Molecule can influence your intimate experiences. Does the Human Brain Make DMT? With scientific evidence showing us DMT in the brain, what can we conclude it is there for? Read on to learn more. How to Use DMT Vape PensRead to learn all about DMT vape pens including: what to know when vaping, what to expect when purchasing a DMT cartridge, and vaping safely. DMT ResourcesThis article is a comprehensive DMT resource providing extensive information from studies, books, documentaries, and more. Check it out! Differentiating DMT and Near-Death ExperiencesSome say there are similarities between a DMT trip and death. Read our guide on differentiating DMT and near-death experiences to find out. DMT Research from 1956 to the Edge of TimeFrom a representative sample of a suitably psychedelic crowd, you’d be hard pressed to find someone who couldn’t tell you all about Albert Hofmann’s enchanted bicycle ride after swallowing what turned out to be a massive dose of LSD. Far fewer, however, could tell you much about the world’s first DMT trip.

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