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B vitamins regulate the immune system and improve cardiovascular and neurological systems

B vitamins are a group of eight micronutrients that are not related to each other and play a significant role in maintaining optimal health.

B vitamins regulate the immune system and improve cardiovascular and neurological systems

They are found in a variety of foods, but certain health factors may increase your body’s requirements.

B vitamins are pivotal to regulating the immune system and helping to prevent a dangerous cytokine storm during a covid infection. Nicotinamide adenine dinucleotide (NAD+) plays an important role in this process and niacin is a building block of NAD.

They are also neuroprotective, playing a role in lowering depression and anxiety, lowering the potential risk of vincristine-induced peripheral neuropathy associated with chemotherapy agents and potentially playing a role in nerve regeneration by supporting cell structures.

Review this list of foods containing the B vitamins and consider limiting sugar and eating fermented foods to increase your production and absorption of the B vitamins in a healthy gut.

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By Dr. Joseph Mercola

One group of eight micronutrients is commonly called B vitamins or B-complex vitamins. These are water-soluble vitamins your body requires for normal functioning. Because they are water-soluble, the body does not store them. Any excess vitamin B you consume during the day is excreted in the urine.

This also means that you must consume these vitamins each day to meet your body’s requirements. They are micronutrients because you only need them in small quantities, yet they play a significant role in optimal health. Despite belonging to the same complex of vitamins, they are not related.

While they are found in a variety of foods, certain factors may increase your need for B vitamins. These factors include your age, dietary choices, genetics, medications, liver disease and alcohol use.1 The eight B vitamins and their function include:2

Irregulated Immune System Raises Risks Linked to Covid

Since 2020, the health condition that’s been at the top of many people’s minds has been covid. I’ve written many articles reviewing how nutrients like vitamins C and D can help prevent and play a role in the treatment of this illness. Another nutrient known to influence your immune system and immune competence is the group of B vitamins.

One factor that makes covid dangerous for people with underlying medical conditions is it over-activates your immune system and triggers a cytokine or bradykinin storm. B vitamins play a role in modulating immune function, which means the immune system functions more effectively and minimises this risk. Dr. Uma Naidoo, a nutrition expert from Harvard Medical school, explains it this way to Yahoo! Life:3

You can think of the immune system as an army. Its job is to protect the body. But if the immune system army isn’t well-regulated, it can overreact and actually cause more damage – this overreaction is what often happens in covid-19 and is referred to as the cytokine storm. Cytokines are inflammatory molecules released by immune cells. They are like the weapons of the immune system army.

So, if immune cells are soldiers, cytokines are guns and grenades. And in a poorly regulated immune system, the body’s cytokine storm induced by covid causes lots of inflammation in the body, just as if little grenades were being tossed around. This is what causes the worst outcomes and death in covid.

A 2021 paper4 stresses the need to highlight the importance of B vitamins as they play a pivotal role in proper immune function. They assist in the activation of both the innate and adaptive responses, as well as reducing proinflammatory cytokines and preventing hypercoagulability. B vitamins not only contribute to a healthy immune system but potentially could prevent or reduce severe symptoms of covid.

The paper detailed the various functions B vitamins have that may be useful in managing covid symptoms. This includes vitamin B1 deficiency that creates an inadequate antibody response, vitamin B5 and B6 deficiencies that may affect inflammation and vitamin B9 deficiency that adversely affects your adaptive immune response as B9 helps prevent the virus from binding to and gaining entry into your cells.

Niacin may be another missing piece to the covid puzzle. A 2021 paper5 awaiting peer review by Dmitry Kats, PhD, focuses specifically on niacin and raises the question of whether this vitamin may be a crucial player in the disease process.

Kats notes that a hallmark of covid is the cytokine storm, which can lead to multiple organ failure and death. By decreasing and controlling these damaging cytokines, you stand a good chance of thwarting the cytokine storm and the downstream damage that it causes. Nicotinamide adenine dinucleotide (NAD+) plays an important role in this process and niacin is a building block of NAD. As researchers in the 2021 paper explain:6

NAD+ is released during the early stages of inflammation and has immunomodulatory properties, known to decrease the pro-inflammatory cytokines, IL-1β, IL-6 and TNF-α. Recent evidence indicates that targeting IL-6 could help control the inflammatory storm in patients with covid-19.

In addition to markedly decreasing proinflammatory cytokines, niacin has also been shown to:7

  • Reduce the replication of several viruses, including vaccinia virus, human immunodeficiency virus, enteroviruses and hepatitis B virus.
  • Reduce neutrophil infiltration.
  • Have anti-inflammatory effects in patients with ventilator-induced lung injury.

Lower Symptoms of Depression and Anxiety with B Vitamins

The need for strategies to lower anxiety and depression rose dramatically during the covid pandemic. Since it’s likely not the last pandemic in the coming months and years, this need will presumably not dissipate. Developing strategies to improve resilience is an important step to protecting your health and the health of your family.

A double-blind 2022 study8 engaged 478 college students over a five-year period during which the participants received one of three options: a lactose placebo pill, 1,000 microgram vitamin B12 tablet or 100 milligrams (mg) vitamin B6 tablet for one month. The researchers used questionnaires and specific visual tests that gave evidence of GABAergic inhibitory interactions to evaluate the symptoms of anxiety and depression.

Gamma-aminobutyric acid (GABA) is a chemical known to inhibit nerve impulses in the brain and thus lower excitability. Vitamin B6 is a coenzyme in the production of GABA and in other pathways that help reduce neural excitability. The participants consumed vitamin B6 or B12 at 50 times higher than the recommended daily dose.

However, as the researchers pointed out, recent evidence demonstrates that while the optimum level of vitamin B has not been established, it “certainly exceeds the Recommended Daily Allowance (RDA) and many individuals are borderline deficient.”9

The researchers found that B6 supplementation lowered anxiety and produced a trend toward lower levels of depression, and B12 supplementation also helped lower anxiety. While there were some limitations to the study, such as not doing a baseline or post-test serum analysis to determine if the participants were deficient or if the supplements raised the serum level, the researchers found that:10

… nutrition-based interventions produce far fewer unpleasant side effects than drugs, and so in the future people might prefer them as an intervention. To make this a realistic choice, further research is needed to identify other nutrition-based interventions that benefit mental well-being, allowing different dietary interventions to be combined in future to provide greater results.

Magnesium is another nutrient that has a powerful effect on depression and anxiety; so much so that Psychology Today calls it the “original chill pill.”11 Researchers have demonstrated that magnesium has a beneficial effect on an individual’s subjective perception of anxiety,12 and that magnesium was effective in the treatment of mild to moderate depression in adults without the need for monitoring for toxicity.13

Magnesium and vitamin B6 work even better in combination. A 2018 study14 highlighted the importance of these two nutrients on mental health. When taken together, animal studies have demonstrated they have a complementary effect on stress reduction.

The research was a Phase IV investigator-blinded trial in healthy adults who received either magnesium alone or a combination of magnesium and vitamin B6. They found those taking the combination had a 24% improvement in stress scores.

Improves Cardiovascular and Neurological Systems

B vitamins are powerhouse nutrients also known to protect your brain and heart. Two that are frequently studied are vitamins B6 and B12. According to,15 one function of vitamin B6 is to help the body maintain normal levels of homocysteine. This is an amino acid that has been associated with dementia, stroke, osteoporosis and heart disease when it is above normal levels.16

A preliminary study17 in 2007 demonstrated that high levels of vitamin B6 helped lower levels of homocysteine in men with schizophrenia and schizoaffective disorder but not women. The data have not consistently shown that reducing homocysteine levels using vitamins B6 and B12 could reduce cardiovascular events.

However, a 2021 study18 assessed the effect of vitamins B6, B9 and B12 on homocysteine levels as it is also related to the risk of stroke, cardiovascular disorders and vascular death. The intervention demonstrated a risk reduction of 11% among stroke patients for the three risks, a 13% reduction for stroke and a 17% reduction for vascular death.

In addition to the effect on mental health, vitamins B6 and B12 have demonstrated properties that protect against peripheral neuropathy. A 2021 study19 sought to evaluate if B6 and B12 could prevent vincristine-induced peripheral neuropathy which occurs in 40% to 45% of patients receiving this chemotherapeutic agent.

Of the 102 patients enrolled, 81 completed the study during which the researchers found a significant difference in the incidence of peripheral neuropathy between the intervention and placebo groups. Data showed an absolute risk reduction of 30% and a relative risk reduction of 54% in the intervention group.

A 2021 paper20 published in BioMed Research International proposed that vitamins B1, B6 and B12 are key players in the protection of the neurological system against environmental influences. They suggest these vitamins may help nerve regeneration by supporting the development of cell structures.

How to Improve Your Vitamin B Status

I generally recommend getting most if not all your nutrition from locally and organically sourced real food. Depending on your situation and condition, however, you may need to consider supplements. Start by reviewing the following list of foods that contain B vitamins. If you find that you rarely or never eat foods rich in one or more of these nutrients, you may want to consider taking a high-quality, ideally food-based supplement.

Also, consider limiting sugar and eating fermented foods. B vitamins are produced within a healthy gut environment. Eating real food, including plenty of leafy greens and fermented foods, will provide your microbiome with important fibre and beneficial bacteria to help optimise your internal vitamin B production.

Sources and References

Featured image: B-Vitamins and The Best Whole Food Sources, Nutri Fusion

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