From ... in Biology — Jul 15, 2024

Dr. Kevin Stillwagon: The human immune system is a marvel of biological engineering

At the heart of our bodies’ defence system is the ability to recognise any foreign proteins that could ever exist, even ones that evil scientists haven’t thought of yet.

The recognition of foreign proteins is by intelligent design and comes from living cells. This extraordinary capability is largely accomplished through a process known as VDJ recombination.

Variable diverse joining (“VDJ”) recombination is the process by which immunoglobulin (antibody) and T cell receptor genes are assembled into functional units during lymphocyte (a type of white blood cell) development. This process is crucial for the adaptive immune system, producing a diverse set of antigen receptors in developing lymphocytes.

Virtually any substance can elicit an antibody response. Furthermore, the response even to a simple antigen bearing a single antigenic determinant is diverse, comprising many different antibody molecules each with a unique affinity, or binding strength, for the antigen and a subtly different specificity. The total number of antibody specificities available to an individual is known as the antibody repertoire, or immunoglobulin repertoire, and in humans is at least 10¹¹ (that’s 10 followed by 10 zeros or 100 billion), perhaps many more.

Diversity within the immunoglobulin repertoire is achieved by several means. Perhaps the most important factor that enables this extraordinary diversity is that V regions are encoded by separate gene segments, which are brought together by somatic recombination to make a complete V-region gene. Many different V-region gene segments are present in the genome of a person, and thus provide a heritable source of diversity. Additional diversity, termed combinatorial diversity, results from the random recombination of separate V, D, and J gene segments to form a complete V-region exon.

Read more: The generation of diversity in immunoglobulins, Immune Biology, 2001

The above is difficult for a layman to understand so Dr. Kevin Stillwagon has produced a short video to explain.

If you are unable to watch the video above on Rumble, you can watch it on Substack HERE.

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Transcript

The human immune system is a marvel of biological engineering, designed to protect us from a vast array of potential threats, including viruses, bacteria and even man-made bioweapons. God designed the human body to be able to do this from birth, and if we could not do this, we would not be able to survive as a species. At the heart of this defence system is the ability to recognise any foreign proteins that could ever exist, even ones those evil scientists haven’t thought of yet. The recognition is intelligent and comes from living cells. It does not come from unintelligent “lock and key” actions of antibodies that are non-living proteins. Antibody actions are secondary, happening only AFTER the intelligent recognition has taken place.

This extraordinary capability is largely accomplished through a process known as VDJ recombination, which is crucial for the development of diverse and specific antigen receptors on B-cells and T-cells. VDJ recombination is a genetic mechanism that generates the diverse repertoire of antigen receptors necessary for the adaptive immune system to recognise a wide variety of pathogens. This process occurs during the early development of B-cells in the bone marrow and T-cells in the thymus gland.

For B-cells: VDJ recombination happens in the bone marrow. The process involves the seemingly random assembly of variable (“V”), diverse (“D”), and joining (“J”) gene segments to create the variable region of the B-cell receptor. Each B-cell ends up with a unique receptor that can recognise ONE specific antigen. So, each B-cell has thousands of receptors that are exactly the same for that B-cell, looking for only one specific protein antigen.

For T-cells: VDJ recombination takes place in the thymus gland. Like B-cells, T-cells rearrange their V, D, and J gene segments to form the T-cell receptor. Each T-cell has thousands of receptors that are exactly the same for that T-cell, looking for one protein antigen.

There are billions of T-cells and billions of B-cells, but they are not all unique. There will be a handful of these cells that are the same and are looking for the same unique protein.

Although the VDJ recombination for B-cells and T-cells are similar, the way they identify the proteins they are looking for are completely different. B-cells can detect free-floating soluble proteins, or something that was injected in a product called a vaccine. But T-cells cannot do that. T-cells can only recognise proteins that are presented to them by APCs or antigen-presenting cells like dendritic cells and macrophages.

This creates a huge problem for vaccines because if the vaccine contains or makes too many antigens, B-cells can directly detect them and start making suboptimal antibodies to whatever was injected.

Conversely, in natural infections, antigen-presenting cells will present smaller protein pieces of the foreign invader to T-cells on major histocompatibility type 2 sites, and those activated T-cells will help B-cells make more refined antibodies against all parts of the invader, not just a piece of it. This makes immunity from a natural infection far superior to any immune response to something that was injected.

The VDJ recombination process is highly complex and allows for the generation of billions of unique B-cell receptors and T-cell receptors. This diversity is essential because only a small subset of these receptors will match any given pathogen. When a pathogen invades, only a handful of B-cells or T-cells, out of the billions produced, will have receptors that can bind to the specific antigens presented by the pathogen. It sounds impossible, but this seemingly improbable matching process works effectively, providing robust protection against a wide array of threats, so there is no need to be afraid of the threats.

It is important to understand that it is the living immune cells – B-cells and T-cells – that actively patrol the body and eliminate infections. Antibodies, which are produced by B-cells, serve only as markers that bind to antigens. They do not destroy pathogens directly but flag them for destruction by other immune cells. The intelligence and adaptability of living immune cells are what makes the immune system so effective. These cells can recognise, remember, and respond to specific pathogens, ensuring long-term immunity.

Despite its robustness, the immune system can be compromised by certain medical interventions. Treatments such as chemotherapy and radiation therapy can damage the bone marrow and thymus, where VDJ recombination occurs, thereby reducing the production of new B-cells and T-cells and impairing immune function. Immunosuppressive drugs, used in conditions like autoimmune diseases or organ transplants, can also inhibit the proliferation and differentiation of lymphocytes, indirectly affecting VDJ recombination. Genetic disorders such as Severe Combined Immunodeficiency (“SCID”) result from mutations in genes essential for VDJ recombination, leading to a lack of functional B-cells and T-cells. And if we’re not careful, the injection of mRNA gene therapies could end up negatively affecting VDJ recombination.

The human immune system’s ability to recognise any foreign protein is critical for our survival. VDJ recombination plays a pivotal role in generating diverse and specific receptors on B-cells and T-cells, allowing the immune system to mount an effective response against a vast array of pathogens. Despite the complexity and seeming improbability of this system, it functions remarkably well, protecting us from countless threats. However, it is important to be aware of medical interventions that can weaken this capability, highlighting the need for careful management of treatments that impact the immune system, especially when it comes to shots called vaccines.

Thanks for reading, and thanks for staying smart.

About the Author

Dr. Kevin Stillwagon is a retired American chiropractor, airline captain, inventor, author and lecturer. He became a chiropractor in 1980, licensed in the states of Florida and Pennsylvania. He self-published a book in 1984 on medical freedom and the dangers of vaccines and has been a medical freedom fighter ever since. He invented and patented a thermographic device in 1985 and taught its use worldwide. He became an airline pilot in 1987. In early 2020, he saw signs that loss of freedom could be worse than the virus and began to speak out at his airline, which forced him to retire because he refused to wear a facemask as part of his uniform.

You can follow Dr. Stillwagon by subscribing to his Substack ‘The Silent Killers’ HERE or on his Rumble channel HERE.

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