General Principles to Consider When Treating Chronic Illness
STORY AT-A-GLANCE Dr.
David Minkoff is a pioneer in natural medicine with an active practice in Clearwater, Florida. In this interview, we dive deep into some of his best strategies to optimize your health and resolve common health challenges that conventional medicine is incapable of resolving. Like me, he's passionate about exercise and has been an avid athlete since his youth. So far, he's participated in 43 Ironman competitions and will be doing another in September 2022.
“Most of my practice is chronically ill people, but I have worked with some veryhigh-end athletes, and I can really help them because I understand what kind ofmetabolism you need to do to be able to perform consistently at a high level,”
“I've sort of been in the laboratory myself, and that's been very helpful.”
Minkoff has had a rather eclectic medical training, including adult and pediatric infectious disease. In 1995, his wife, a registered nurse, took him to a series of Jeffrey Bland lectures, a pioneer in nutritional biochemistry, and the rest, as they say, is history.
“My lights just went on,”
“It was just like, ‘Holy smokes, this guy issmart, and it makes sense, and I want to learn this.' So, I started going tocourses. I went to ACAM [American College for Advancement in Medicine] andlearned how to do chelation.”
After that, he trained with Dr. Dietrich Klinghardt, a biological dentist and Lyme disease specialist; Dr. Yoshiaki Omura, a general practitioner, cardiologist and president of the International College of Acupuncture and Electro-Therapeutics; and Dr. Thomas Rau, a Swiss doctor specializing in biological medicine.
“As I got into it, I just sought out the best people that I could find to help melearn how I could do this better,”
“That's been 25 years. So, I leftthe emergency room in 2002, and we've been going gang busters since then.We have a very big practice now, and it's so much fun because there are somany new ways to help people get better that actually solve the problem withtheir bodies.… If you have a chronic illness — high blood pressure, high cholesterol,rheumatoid arthritis, Parkinson's disease — the repertoire of standard medicineis not very good. They might help you with symptoms, which is fine for a while,but you are headed toward an endpoint, which isn't going to be what you want.We have seven hyperbaric chambers. We've been doing it for years. It's awonderful treatment ... We've been doing methylene blue for about five years ...Then, I learned about intranasal NAD — fascinating. The field is exploding withamazing people who are coming up with things that help people and havepractically zero downside.”
Two Key Root Causes
Chronic illness is typically caused by some underlying cellular dysfunction, and two of the primary reasons for that are toxicity and/or poor gut health. Minkoff explains:
“Half the problem is things in the body that shouldn't be there, and the other halfis things missing from the body that should be there. In some cases, there'smechanical stuff.We need chiropractors, acupuncturists, massage therapists or things like thisbecause there's a joint out of place, or their cervical vertebrae are out of place.Sometimes they might even need surgical intervention.But the big two are, you're toxic and you're depleted. My approach to peoplethen is: What are those things, and then, what is the priority or the order ofdealing with those things?”
When it comes to detoxification, many things can go wrong, so it needs to be done under the supervision of a skilled practitioner. The use of DMPS, for example, can be very rough on your kidneys, and if your body is not capable of excreting the toxins, releasing them from the tissues where they're trapped will make you far worse rather than better.
Making a Diagnosis
When Minkoff sees a new patient, he has them fill out an extensive and detailed medical history, including dental history. Then, he performs a detailed physical exam, followed by autonomic response testing, which allows him to identify various triggers, such as toxins and infections.
“The body is so sophisticated that it will give you a sort of readout of ‘Here's mypriority levels. Do the root canals first. Handle the cavitations. Oh, yes, there's aparasite there. There's autoimmune there. I've got chronic Epstein Barr virus orherpes Type 6,'”
Minkoff explains. Autonomic response testing will also identify specific pathogens that are causing problems. In the interview, Minkoff gives a number of examples of patients whose health problems were resolved once the specific pathogen was identified and treated.
With oxygen, you can stimulate a body to heal. Youcan stimulate a joint cartilage to grow. You canstimulate a tendon to strengthen and you canstimulate an immune system to get stronger. You cankill off bugs, Lyme, and put viruses at bay. It's just amassive game changer. ~ Dr. David Minkoff
Oftentimes, an infected root canal is found to be the offender. Minkoff has a biological dentist nearby. If a dental problem is suspected, he'll send the patient there for a three- dimensional cone beam CT scan, which can clearly identify any problem areas that aren't visible using a two-dimensional X-ray. Another really helpful diagnostic is darkfield blood analysis (aka, live-cell microscopy), which Minkoff learned to use under Rau.
“I find that it's very helpful because sick people have bad-looking blood,”
“Their physical examination is often fine, their refiexes are fine, their heartsounds fine and their liver and kidney are fine [but they feel terrible] ... We throwthe blood up on there and look at it and we're like, ‘Holy smokes.' There are bio-films all over, there's fibrin deposits and there's organisms ...Two months later, ‘Hey, look at this blood. This blood's looking better.' And twomonths later, ‘This blood is really looking normal' ... That's a complete picturewhere we are restoring healthy physiology to this person and that's what healthis.”
Available Treatment Modalities
When it comes to treatment, Minkoff has a number of interesting modalities at his disposal, including prolotherapy, ozone therapy, prolozone (a combination of prolotherapy and ozone), hyperbarics, chelation, UVBI (ultraviolet blood irradiation), EBOO (extracorporeal blood oxygenation), photobiomodulation and much more. Minkoff also offers VSELs [very small embryonic like] stem cell treatment, and it too has potent effects. Minkoff uses it himself and attributes gaining 7 pounds of lean body mass without change in his training to VSELs. He was trained in the use of VSELs by Dr. Todd Ovokaitys in San Diego. Dr. Frank Shallenberger is the physician who trained him in ozone administration. Interestingly, Minkoff and I are both scheduled to speak during Shallenberger's 2022 ozone certification course at the Peppermill Resort and Casino in Denver, Colorado. The course is for medical professionals only, not for lay people. If you know any clinicians who are interested in this important modality, please encourage them to attend. Minkoff and I would look forward to connecting with them.
Benefits of Extra Corporeal Oxygen and Ozone (EBOO) Therapy
EBOO is the newest and most potent way to administer ozone. It is even more effective than 10 pass ozone, but most people have to start slowly and work their way up to it. I became fascinated with this treatment last year and encouraged Tom Lowe to make the units available commercially in the U.S. Minkoff explains:
“EBOO is a way to deliver oxygen and ozone to the body in a setup that's likedialysis. One IV goes into one arm, it goes through a machine that has a pump,so it can pull the blood out of the body. It goes through a system where theblood is exposed to oxygen in very high concentrations and ozone in lowconcentrations, and then it's recycled back to the body.Some of the new machines also expose the blood to ultraviolet light. For aboutan hour, the blood circulates through this machine and is highly oxygenated. Itisn't really filtered like dialysis would be, but it's exposed to this high oxygenconcentration.And — I don't exactly understand how it happens — but there is a runoffcontainer where if you are really sick and toxic, you get a lot of this runoffcollected in this container. Sometimes it's foamy and yellow. Our record is 2,000CCs of this foamy liquid in a really sick person ...”
Sauna therapy is another excellent intervention with powerful therapeutic benefits. We didn't get a chance to dive deep into sauna treatment but I should have an incredibly extensive and detailed deep dive on saunas in the next week that provides specific recommendations on how to identify and/or build one of the best saunas in the world. This is one of my favorite therapies and I believe most can benefit from them, so stay tuned for this important article.
How to Raise NAD Naturally
If you don't have access to IV NAD treatment or can't afford it, there are three ways to raise your NAD level naturally: calorie restriction (or time-restricted eating, which achieves the same thing, but is safer), aggressive exercise and sauna therapy. If you do those three things, you'll activate NAMPT, which is a precursor to NAD. You could then use low-dose niacinamide (not niacin). An ideal dose is around 50 mg, three times a day. This will give you the raw material your body needs to produce NAMPT. I did an excellent interview with molecular biologist Nichola Conlon earlier this year which you can find on my Substack. “I put a lot of people with mitochondrial issues on [niacinamide], and I found that it's helpful,” Minkoff says. Niacinamide is also extremely cost-effective. It'll run you about 25 cents a month, whereas other NAD precursors such as NMN can cost you $100 a month or more.
Plasmalogen and Iron Testing
Minkoff also uses a lipid test developed by lipid biochemist Dayan Goodenowe, author of “Breaking Alzheimer's.” “I've learned a ton from him, and we do his test on everybody,” Minkoff says.
“He's got a lab now that can measure levels of plasmalogens. They're veryintegral pieces of cell membranes, and he's got some very nice data aboutpeople with APOE4 on a track of memory loss.”
Patients with low plasmalogen levels can be given supplements such as fossil lipids to prevent further deterioration of their neurological function. Minkoff also measures ferritin and iron binding on all patients, and if their hemoglobin is high, he prescribes blood donation to lower their stored iron. Stored iron is incredibly destructive, as it causes oxidative stress, and is a commonly overlooked factor in deteriorating health.
Basic Health Guidance
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