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From ... in Biology —

How Colostrum Can Benefit Your Immune Health

STORY AT-A-GLANCE For the first three to four days after giving birth, all mammals, including humans, produce colostrum, also known as initial milk or first milk.

How Colostrum Can Benefit Your Immune Health

Rich in enzymes, hormones, growth factors, cytokines and immune cells, this thick, yellow substance is produced only in small quantities, but is packed with so much nutrition that it easily meets the needs of the growing newborn during the first days of life. About 250 active compounds have been identified in colostrum, but there are likely many others. Colostrum contains beneficial bacteria, as well, and acts directly on the baby's tissues, ensuring optimal growth and development of the nervous, digestive and

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immune systems. As explained by researchers with Hirszfeld Institute of Immunology and Experimental Therapy in Wroclaw, Poland:

"The nutrients and regulatory substances ensure normal growth, differentiation,maturation and function of the digestive system, protect against damage andallow it to heal, control the development of a normal intestinal microbiota andshape the local (gut-related) and systemic immune response."

Given the immense benefits of colostrum to newborns, it's also been harnessed for its disease prevention, wellness and antiaging potential, particularly as it relates to immune system function.

Colostrum for Immune System health

Bovine colostrum contains similar bioactive components as human colostrum, albeit in different concentrations. Given its widespread availability, it's been used for health purposes for thousands of years, including to heal wounds and protect against infection. It's believed that cytokines, immunoglobulins, growth factors, antimicrobial compounds and maternal immune cells are also transferred when colostrum is fed, supporting immunity. In fact, colostrum is so beneficial it's often referred to as "liquid gold" or "immune milk." "Naturally produced bioactive components, immunoglobulins lay the foundation of life-long immunity," researchers explained in Food Bioscience. Immunoglobulin G (IgG) is the most common antibody in bovine colostrum (BC), making up 80% to 85% of the immunoglobulin present. The Food Bioscience team noted:

"Before the invention of all the artificial antibodies, colostrum was used as akey to unlock all mechanisms to prevent microbial infections. Immunoglobulinsare well known for their health benefits to humans in terms of immunogenicresponse. When hosts are exposed to foreign bodies (antigens), theseantibodies bind, recognize, and destroy the bacteria, toxins, viruses, and otherantigens.
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Then, the next time when an antigen enters the body; it stimulates theproduction of identical antibodies to wipe out the infection from the body. Theimmunoglobulins (Igs) present as the major group of immune components inBC are around 100-fold greater than in mature milk.However, the concentration of immunoglobin IgG in BC and mature milk rangesfrom 15 [to] 180 g/L versus 0.35 g/L, respectively. The elevated levels of IgGs inBC exhibit numerous immuno-modulatory properties based on theirimmunoprotective actions reported by several investigators."

In Ayurveda, bovine colostrum is used to irrigate the eyes and treat eye infections, while consuming colostrum is used for a variety of immunity-related disorders, including allergies and autoimmune disorders, as well as cardiovascular disease and microbial and viral infections. Further, bovine IgG is known to bind to human pathogens and allergens, and to neutralize infection in human cells during trials. It also limits gastrointestinal infiammation. Writing in Frontiers in Nutrition, scientists added:

"Furthermore, bovine IgG binds to human Fc receptors which, enhancesphagocytosis, killing of bacteria and antigen presentation and bovine IgGsupports gastrointestinal barrier function in in vitro models. These mechanismsare becoming more and more established and explain why bovine IgG can haveimmunological effects in vivo.The inclusion of oral bovine immunoglobulins in specialized dairy products andinfant nutrition may therefore be a promising approach to support immunefunction in vulnerable groups such as infants, children, elderly andimmunocompromised patients."

Colostrum Works Better Than Flu Shot for Flu

In another example of colostrum's antiviral potential, researchers looked at a combination of colostrum and Bifivir — a supplement containing five strains of bacteria

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and prebiotic fiber — compared to fiu vaccination for fiu prevention. Four groups of individuals were matched for age and sex distribution. In the control group, participants did not receive any preventive measures, which resulted in eight major episodes and 12 minor episodes of fiu. Those who received only the vaccine showed a similar response with eight major episodes and 13 minor episodes. In the group receiving the fiu vaccine and the immunomodulators Bifivir and colostrum, there were four who had a major episode and nine with a minor episode. But the group that received only the immunomodulators faired the best. There were three with a major episode and eight with a minor episode. The researchers found the groups who received vaccinations and the immunomodulator and the group that received only the immunomodulators showed significantly lower rates of fiu when compared against the other two groups. "In conclusion, the administration of immunomodulators is very cost effective and appears to be more effective than vaccination to prevent fiu," the researchers explained. In another example of colostrum's benefits for immunity, 29 road cyclists took either a placebo or bovine colostrum after normal training or a period of intense exercise — five consecutive days of high-intensity training. Low-dose bovine colostrum protein concentrate supplementation modulated immune parameters after both events, and likely contributed to reduced upper respiratory illness seen in the colostrum group.

Colostrum Helps Prevent Upper Respiratory Tract Infections

It's not only athletes who may benefit from colostrum's beneficial effects against upper respiratory tract infections. Another study gave medical university students bovine colostrum or placebo for 45 days, then again over a seven-day period starting at day 87. Both a "high stress" medical student group — considered at increased risk of developing infection — and a lower risk peer group were included.

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The colostrum group had significant protection from upper respiratory tract infections, including fewer symptomatic days and less severe symptoms. However, colostrum supplementation was particularly beneficial in warding off respiratory infection, and improving well-being, in those under a lot of stress and therefore at higher risk of developing such infections. No adverse effects were reported. Bovine colostrum also raises the percentage of natural killer (NK) cells in the body. NK cells are a type of white blood cell and part of the innate immune system that helps control microbial infections and tissue damage. They also play a role in organ transplant, immunotherapy and autoimmune disorders. In a 2012 study on mice, oral administration of skimmed and concentrated bovine late colostrum was shown to activate the immune system and protect against infiuenza infection by boosting NK cell activity.

Colostrum for Gastrointestinal Health

Colostrum's ability to heal the mucosal barrier in the gut also makes it ideal for gastrointestinal health, especially in disorders that involve failure of the mucosal barrier, such as infiammatory bowel disease, infectious diarrhea, necrotizing enterocolitis and damage caused by nonsteroidal anti-infiammatory drugs (NSAIDs). "In human trials, there is substantial evidence of eficacy of bovine colostrum in infiammatory bowel disease and in infectious diarrhea," researchers wrote in a Nutrients review, adding:

"Bovine colostrum is a complex biological fiuid replete with growth factors,nutrients, hormones, and paracrine factors which have a range of propertieslikely to contribute to mucosal healing in a wide range of infective,infiammatory, and injury conditions. Evidence is building that these propertiesmay be employed in several disorders to promote recovery or in prevention."

Among children, colostrum supplementation significantly reduced stool frequency and diarrhea due to rotavirus or E. coli. In adults, it was also effective in protecting against

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travelers' diarrhea. Colostrum also shows promise for reducing infiammatory markers and protecting against intestinal damage caused by chemotherapy treatment and NSAIDs, while also improving symptoms in patients with IBD when used in enema form.

What Else Is Colostrum Good For?

There are more than 120 clinical trials underway looking into colostrum's effects on human health. It's receiving increased attention as a supportive supplement for athletes, particularly during periods of high-intensity activity to benefit body composition, physical performance, recovery and immune function, reducing illness risk and gut damage. Colostrum is also being studied for use in skin care due to its anti-infiammatory effects and ability to stimulate repairs in the skin. In an animal study, a combination of colostrum and honey effectively reduced scars and pain while protecting against infection and stimulating the growth of granulation tissue in wounds. Colostrum is also a rich source of lactoferrin, a glycoprotein with antibacterial, antifungal, antiviral, antiparasitic, antitumor and immunomodulatory effects, which also plays a role in bone regeneration. Overall, colostrum has the potential to infiuence the human body on a systemic level, offering benefits to the following conditions: Brain — depression, anxiety, attention deficit hyperactivity disorder, neurobehavioral dysfunctions Colon — leaky gut, constipation, diarrhea Cardiovascular disorders — atherosclerosis and heart disease Wound healing — repairing DNA and RNA, growth of nerve cells, skin Neuroendocrine system — hypothalamic- pituitary axis, HIV-associated Antiaging — healing process, antioxidant

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immunomodulation Athletic performance — ligament and muscle healing, increased lean muscle mass Other — Type 2 diabetes, Alzheimer's disease When choosing a colostrum supplement, look for a source that comes from grass fed, pasture-raised cows. Start with a lower dose of a few grams per day and increase as needed. While some people use colostrum daily, others use it for more targeted purposes or cycle on and off it.

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