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From ... in Biology Health —

How Iodine Deficiency Increases Your Risk for Chronic Illnesses

Editor's Note: This article is a reprint.

How Iodine Deficiency Increases Your Risk for Chronic Illnesses

It was originally published November 1, 2017. Iodine is essential to your health. Unfortunately, data collected by the U.S. National Health and Nutrition Examination Survey has revealed a significant drop in median urine iodine values. The median iodine level measured in urine samples was 320 micrograms per liter (mcg/L) between 1971 and 1974. By 1988, it dropped to 145 mcg/L. Surveys taken in the years since show levels have stabilized, except in pregnant women whose median urine level dropped further to 125 mcg/L. Many people don't know they need to consume a little iodine each day to maintain healthy levels of this essential micronutrient. Your body uses iodine across several organ systems, but it is most commonly known to synthesize thyroid hormones that

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regulate nearly every bodily system. Several thyroid hormones secreted by your thyroid gland are transported throughout your body where they control your metabolism and energy production. This means that every cell in your body depends on the production and function of thyroid hormones. Your thyroid gland is under the control of your pituitary gland that is located at the base of your brain. In turn, the pituitary gland is under the control of your hypothalamus. In other words, there are several steps needed to identify low thyroid hormone levels and to tell your thyroid gland to begin secreting more. A 2017 study published in the British Journal of Nutrition evaluated the iodine levels of cow's milk and milk alternatives in search of a potential reason for this growing iodine insufficiency.

Milk Substitutes Are Low in Iodine

Researchers from the University of Surrey evaluated the iodine content in 47 milk alternatives and compared those levels to cow's milk. The researchers included almond, soy, coconut , rice and hazelnut milk alternatives, but excluded products marketed specifically for infant consumption. They discovered the majority of brands did not have adequate levels of iodine as compared to cow's milk. Most contained only 2% of that found in cow's milk. Only three milk alternatives were fortified with iodine. This means that opting for a milk alternative may increase your risk of developing an iodine deficiency, as the milk alternatives tested only provided 2 mcg per serving, while 2 cups of cow's milk will cover your recommended dietary allowance (RDA) of iodine . Statistically speaking, you may have difficulty absorbing milk products , which means you would have a negative reaction when you drink cow's milk. According to the U.S. National Library of Medicine, approximately 65% of all people have difficulty digesting lactose after infancy.

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Lactose is the sugar found in cow's milk. This intolerance or allergic reaction to milk sugar is the reason some turn to milk alternatives. Margaret Rayman, professor of nutritional medicine at the University of Surrey, said: “Many people are unaware of the need for this vital dietary mineral and it is important that people who consume milk-alternative drinks realize that they will not be replacing the iodine from cows' milk which is the main UK source of iodine. This is particularly important for pregnant women and those planning a pregnancy. A glass of a milk-alternative drink would only provide around 2 mcg of iodine which is a very small proportion of the adult recommended iodine intake of 150 mcg/day. In pregnancy, that recommendation goes up to 200 mcg/day.”

Iodine — An Essential Micronutrient

Iodine is an essential micronutrient that helps alkalize your body's pH, provides your thyroid with the necessary nutrients to produce thyroid hormones, protects against cancer and is a natural antibacterial agent. In this short video, iodine expert Dr. Jorge Flechas explains how iodine affects your health well beyond your thyroid gland. Your thyroid hormones are essential for normal growth and development in children, neurological development in babies before birth and in the first year of life, and in regulating your metabolism. Deficiency may be most damaging to the developing brain and could result in miscarriage, preterm birth or neurological impairment in a newborn. Before moving forward, let's clarify the difference between iodine and iodide. Iodine is the molecule that is taken up by cells in the body. However, iodine is not very available in food and supplements. Iodide, having greater stability, is the form typically found in supplements. In your body, the iodide molecule is converted into iodine, which is the active form needed by your thyroid gland. The RDA is 150 mcg per day for adults, 220 mcg/day for pregnant women and 290 mcg/day for women who are breastfeeding. However, as evidenced by dropping levels

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of median urine levels, most adults are not consuming enough iodine each day to meet the minimum levels required for health. The World Health Organization (WHO) defined iodine deficiency in large populations as median urinary concentrations of 99 mcg/L or less. These low levels of iodine would likely result in visible symptoms, such as a goiter (swelling of the thyroid gland), hypothyroidism or pregnancy-related problems. More insidious are problems with subclinical deficiency, or levels that can't support optimal health but are not low enough to create immediate life-threatening problems.

Your Risks of Subclinical Iodine Deficiency

Risks of subclinical iodine deficiency are not limited to pregnancy and infant neurological development or weight gain. Nearly 2 billion people worldwide don't get enough iodine in their diet, and 50 million suffer from brain damage caused by the deficiency. This may very well be the most preventable cause of brain damage in infants and children, and yet 36.5% of children are estimated to have an iodine deficiency. Even a small deficiency in an adult's iodine level may reduce your IQ by up to 15 points, which may affect your ability to get a job and keep it. Subclinical iodine deficiency, also known as iodine deficiency disorder (IDD), is subtler than a goiter and may be more dangerous. Iodine helps lower the risk for reductive stress that may lead to chronic diseases, such as diabetes, atherosclerosis and arthritis. When your thyroid is not fully functional it can also lead to heart disease. Other tissues in your body also use iodine in appreciable amounts, including: Salivary glands — Low levels of iodine may lead to dry mouth. Skin — Your body uses iodine in the development of skin, teeth, nails and bones. Low levels of iodine may lead to acne.

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Eyes — Iodine is an antioxidant that naturally protects your eyes against ultraviolet radiation. Immune system — Iodine is a scavenger of free hydroxyl radicals and stimulates the activity of other antioxidants. Muscles — Iodine deficiency may lead to pain, fibromyalgia and muscle weakness. Pancreas — Radioactive iodine therapy is a common therapy in thyroid cancer. Studies demonstrate that radioactive iodine is absorbed by the pancreas and predisposes you to glucose intolerance. Stomach — Iodine is used by the cells lining your stomach to concentrate chloride to produce hydrochloric acid used in the digestion of your food.

Iodine Protects You Against Cancer

Iodine functions in a protective role against the growth of cancer cells. Although the exact mechanism is unknown, researchers have found that cancer cells shrink after injection with iodine and some die and are then replaced with healthy cells. Iodine is also involved in apoptosis , or programmed cell death necessary for the development of new cells and removal of malignant or diseased cells. The incidence of thyroid cancer has increased worldwide, driven in part by better screening that may pick up small benign tumors, which otherwise would not have caused a medical problem. However, this has also coincided in the U.S. with a reduction of iodine intake. Some studies have suggested that prophylactic iodine in deficient populations may reduce the diagnosis of more aggressive forms of thyroid cancer. Iodine is also vital to breast health in women who are breastfeeding and in older women. A deficiency may lead to fibrocystic disease or breast cancer. Human breast tissue and breast milk contain higher concentrations of iodine than your thyroid gland, as iodine is essential to the development of a newborn's brain.

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However, it also plays an important role in the health of the breast tissue as it exerts a powerful antioxidant effect. Breast tissue deficient in iodine has elevated markers of lipid peroxidation, one of the early signs of cancer development. Breast tissue that is iodine-deficient also demonstrates increases in estrogen receptor proteins and alterations in DNA. When a woman's iodine levels are low, it stimulates the ovaries to produce more estrogen, which stimulates growth in breast tissue. Iodine also helps regulate cortisol, which is associated with a higher risk of breast cancer. When you compare Japanese and Western diets against the incidence of cancers, these differences become even more apparent. Breast cancer rates for women living in Japan and eating a diet high in iodine are 66% lower than for American women. However, once a Japanese woman moves to the U.S., her breast cancer rate rises to the level of American women. Cells that line your stomach also capitalize on the antioxidant effects of iodine. Those living in iodine-deficient populations have a higher incidence of goiters and stomach cancers. An increase in iodine intake has been strongly correlated with a reduction in the incidence of stomach cancer.

Iodine Deficiency Affects More Women Than Men

Women are much more likely to develop symptoms of hypothyroidism. Edward Toromanyan, chief endocrinologist of the Ministry of Health of Armenia, notes, "According to different research, women are having problems with thyroid gland three to 10 times more than men. This also applies to toxic goiter and insufficiency of thyroid hormones." In the U.S., hypothyroidism disproportionately affects women more than men, likely because the female hormone estrogen inhibits the absorption of iodine, while testosterone may promote the absorption of iodine. Therefore, what little iodine you consume from your diet is absorbed and used differently based on your gender.

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According to Flechas, hypothyroidism is associated with 80% to 90% free estrogen levels. This means the lack of iodine increases free estrogen levels that stimulate growth in breast tissue. The normal value of free estrogen is 40% to 60%. On the other hand, hyperthyroidism is associated with only 20% free estrogen. The interplay of estrogen, thyroid hormone and iodine is a complex mechanism and increases a woman's risk of iodine deficiency.

Chemicals in Your Environment Also Block Iodine Absorption

While women have a greater incidence of iodine deficiency related to their hormone production, everyone experiences poor absorption and utilization related to environmental contamination. Some contaminants that compete with iodine include: • Fluoride — Fluoride is a halogen that has an atomic weight lighter than iodine and can grab receptor sites more easily, thus taking the place of iodine resulting in a deficiency in your thyroid, stomach cells, ovaries and other organs. • Bromide — Iodine used to be used in processing flour. However, manufacturers have replaced it with bromide, another halogen with a lower atomic weight than iodine. This switch effectively reduced your consumption of iodine and injected an element that competes with iodine in your body. • Perchlorate — This is a contaminant found in the groundwater across the U.S. and in measurable amounts in milk, fruit and vegetables. In high doses, perchlorate may inhibit the function of your thyroid gland, but even in low doses, it inhibits the uptake of iodine by your thyroid gland, leading to hypothyroidism. • Nitrates — This may interfere with the uptake of iodine in your thyroid. Avoid added nitrates you find in processed meats, such as luncheon meat, sausage, bacon, hot dogs and some packaged seafood. • Mercury — There is evidence that iodine may help detoxify your body of toxic mercury , found in fish, dental amalgams and consumer products such as antiques, electronics, batteries, light bulbs and pharmaceutical products.

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Iodine Sources

Before the 1920s, the Great Lakes, Appalachians and Northwestern regions of the U.S. were known as the "goiter belt," as 26% to 70% of children suffered from goiter. An iodine prophylaxis program was begun in Ohio in 1917 with over 2,100 schoolgirls. In the following years, the researchers found a significantly decreased frequency of goiter in the girls who received the iodine supplement over those who did not. It wasn't until 1924, after a successful iodination program in Switzerland and spurred by a series of reports, that table salt was fortified with iodine. However, research has found varying degrees of iodine in salt labeled iodized, and 53% of the samples had much less iodine than was listed on the label. Experts believe the declining levels of iodine in the U.S. population may be the result of several factors, including: Eating less salt in the mistaken belief that it is bad for your heart Consuming more dairy substitutes low in iodine, such as almond, hazelnut or hemp milk Snacking on junk foods that are not salted with iodized salt Eating foods grown in iodine-depleted soil Drinking less dairy, which is often a primary source of iodine Eating little to no iodine-rich sea plants, such as kelp Foods that contain higher amounts of iodine include sea vegetables, such as kelp, kombu and wakame. Kelp has the highest amount of any food and just one serving gives you four times the RDA. You can read more about the restorative benefits of kelp in my previous article, " Seaweed Is the Next Trendy Superfood ." Organic, grass fed butter is another source of iodine and healthy fats in your diet. Grass fed butter is also high in vitamins, glycosphingolipids and conjugated linoleic acids that are important to support your overall health. You can read more about the benefits of grass fed butter in my article, " Butter Is Booming ."

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