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Mistletoe and the Emerging Future of Integrative Oncology

STORY AT-A-GLANCE In this interview, Dr.

Mistletoe and the Emerging Future of Integrative Oncology

Nasha Winters, coauthor of “ Mistletoe and the Emerging Future of Integrative Oncology ,” reviews some of the benefits of this ancient herb in the modern world of oncology. Winters is herself a cancer survivor, so this topic is close to her heart.

“I'm coming on 30 years out of a death sentence, a terminal cancer diagnosis,”

she says,

“and still to this day get met with so much resistance to what I've
learned for myself, and for thousands, if not tens of thousands, of otherpatients directly, as well as way more than that, indirectly, through the trainingof their physicians ...My crazy controversy is that I focus more on the human organism and thehealth of that terrain versus the condition, the disease or the label that overlaysthat person.”

Mistletoe Has a 100-Year Oncological History

Mistletoe, a semi-parasitic plant that grows in the branches of trees all over the world, has been used as a herbal medicine for thousands of years for conditions such as epilepsy, spleen disorders, pain and rheumatic conditions. Just over 100 years ago, in 1917, Rudolf Steiner, a philosopher with incredibly keen observation skills, noticed the mistletoe looks a lot like a tumor, and proposed it might have anticancer properties. Many vitalistic medical practices, such as Ayurveda, Chinese medicine, naturopathy and homeopathy, for example, use the doctrine of signatures, which is what Steiner was suggesting.

“For instance, you look at a walnut and it kind of looks like a brain and we think,I wonder if that's any good for the brain? And sure enough, we find somesignificance in how it impacts the brain. Or things like lungwort. When you lookat it, it looks like a lung and we've learned that this herbal medicine is veryhelpful for lung conditions,”

Winters says. A Swiss doctor named Ita Wegman applied Steiner's observation of mistletoe to see how it would impact a patient with cancer, and the plant has since enjoyed over 100 years of consistent application in oncology, both standalone and as adjuvant support.

“Interestingly enough ... Steiner understood that you needed to harvest differentcomponents of the plant — berries that bloom in the winter, which is veryabnormal, and the leaves that grow in the summer ... and grow inward.It has a very interesting behavior compared to other plants, and that was anobservation of how cancer works as well. It goes against the rhythm. It growsout of sync with the organism. That is very much what he recognized.And as such, he harvested the plant and aspects of the plant at different times,blended it, and then took a particular extract from it. He also noted that itneeded to be injected, because you need to remember, 100 years ago we didn'tknow about lectins, we didn't know about viscotoxins, yet somehow, heunderstood that you needed to inject it to get the anticancer benefit.You could take the full tincture. You could take it in other ways, and it has a lotof other medicinal impacts, but then it doesn't have the anticancer impacts, thereason being, we've learned — or at least we suspect, because we're stilllearning — is that those lectins and things get broken down in our GI tract andthey don't get into the bloodstream; they don't access the immune system in theway they need to ...”

Mistletoe Can Be Used as an Adjunct for All Cancers

According to Winters, mistletoe is likely to be useful as an adjunct therapy for all cancers, and she, along with several other doctors, has been training physicians on how to use mistletoe for several years now.

“One of our physicians has been using mistletoe for 45 years in his practice,and what we've seen clinically, and what the research suggests, is that thistherapy, it has always been about using it with others. It plays very well withothers.It was never really developed to be a standalone therapy, though believe me,we've seen impact with that as well. And it has virtually no contraindicationswith any of our standard of care therapies. So, we can literally inject this into apatient the morning before they go into a surgery, or they can start on thistherapy the very day they're going to start a round of chemotherapy or radiation.It bypasses first phase detox pathways of the liver, so it doesn't interact,intervene, speed up or slow down detox processes that could otherwise causesome adverse events, or change the desired effect of a certain medication,herbal intervention or dietary intervention.”

Mistletoe Is a Key Cancer Treatment Adjunct

In fact, mistletoe has been shown to enhance other interventions. Even the most toxic treatments seemingly work better and with fewer adverse effects when combined with mistletoe.

“This should be utilized, in my personal opinion, with every patient goingthrough a standard of care approach to just enhance their experience withtreatment,”

she says.

“There are a lot of things that we kind of have to be careful with ... butmistletoe, in my experience, and that of my colleagues, is that this is probablythe least harmful and least contraindicated substance and therapy I've ever hadthe privilege of working with. It's pretty extraordinary and rare to find somethingthat is this applicable to the masses ...As I said, it has over 100 years of continuous use, and has over 250 very goodrandomized studies ... It just completed a Phase 1 clinical trial at John'sHopkins in the United States as an IV application for solid tumors, and is gettingready to be moved into a Phase 2 clinical trial.It is the most studied integrative oncology therapy in the world, and it is utilizedin upwards of 60% to 80% of all cancer patients in Europe. In parts of South andCentral America, all over Southeast Asia and India, in different parts of Europe,this is just part of their medical system ... It's just in the United States where wehave a little bit of resistance to embracing it into our conventional medicalsystem ...As a naturopathic physician who's been practicing integrative oncology forsome time and who has teachers, mentors, colleagues from all over the world,some of the most powerful anticancer therapies I've seen that are beneficialeven to the standard of care model of treatment — things like artesunate,curcumin, quercetin, green tea extract, all of those in intravenous forms — havebeen taken out of our ability to use here in the United States.Do my colleagues still find workarounds to get access to these very importantmedicines? Absolutely they do, but they have to tread very carefully and verylightly. But again, you go north of the border or south of the border and you haveno problem accessing these therapies. Or go to Europe — and this is what I'vebeen doing for the last two years.These treatments that we've had great success with have been plucked out ofour ability to access easily, readily, legally, so we're now having to send ourpatients abroad for them to actually get good cancer care.That's what's really devastating to me. So, another part of my purpose andmission is to build an in-house residential research institute and integrativecancer hospital right here on our soil so we don't lose access and patients don'tlose access [to helpful remedies].”

Arizona Research Facility

Winters is currently building that research institute in Arizona, which will be funded entirely by private donations and research grants. Thousands of patients are anxiously waiting for the doors to open. When asked if she isn't worried our pro-pharma agencies might shut them down, she replies:

“We will be doing all of our due diligence to let people know that these are notFDA approved therapies, that people are coming into a research environment.They're either paying cash or they're getting grants based on their financialability to help them cover this care.We're doing it in a pretty open-minded medical state; Arizona has one of thebroadest scopes of practice in the country. And we're also very close to oursouthern border with Mexico, so that if we do come up against someoneshutting down one of our therapies for a bit, we are able to take our patientsacross the border to a little sister clinic to keep the continuity of care.We don't anticipate that happening because people are coming as a buyerbeware. They're coming being well-informed about who we are and what we'reabout. And frankly, we get thousands of inquiries a month from all over theworld looking for this approach. The patients will drive this home.It's a mighty David versus Goliath story, especially now, but I also think the timeis now because we have these acts, like the Right to Try Act, and because we dohave more and more patients facing this diagnosis with grim outcomes.And, a study that came out in the last year that looked at 17 years' worth ofconventional cancer treatments found that, overall, of the 96 different drugsthey looked at, the average survival rate was 2.4 months. That is the reality andthis is what's driving the clinical oncologists from around the world to sign upand take my course ...So, there is this massive kind of underground movement that's starting tosprout and come above ground. That's happening. And frankly, mistletoe is oneof the vehicles for that to happen ... Instead of trying to fix the model, we're justcreating a new one.”

Another potential “back door” is to convince insurance companies that this is in their best interest. Mistletoe is a natural remedy and therefore cannot be patented, so there's no incentive for the drug companies to pursue it. But insurance companies may support its use once they realize how much money they can save on hospitalizations, drug coverage and everything else.

Mistletoe Modulates Immune Function

Your immune system and metabolic function are both integral parts of addressing cancer, and mistletoe works on both. It's important to recognize, however, that it's not a magic bullet. If you're eating a standard American diet and are metabolically dysfunctional, mistletoe is not going to be as effective as for someone who is also eating a healthy whole food diet and supporting their health in other ways. That said, mistletoe is an immunomodulator. Immune therapies are all the rage right now, with a majority of research dollars being funneled into them. Yet the effectiveness rate for these therapies is less than 20%. In other words, they're hardly a cure.

“A lot of folks have heard of Jimmy Carter's melanoma story that hadmetastasized to his brain. He took this immune drug, Keytruda. That's acheckpoint inhibitor. The most common drugs you'll hear about are things likeOpdivo, Keytruda, PD-1, PDL1 inhibitors, those are checkpoint inhibitors, orCTLA-4 inhibitors, also a type of checkpoint inhibitor.These are drugs that kind of pull the breaks off your immune system to go hogwild in treating the cancer. Now that seems like a great idea — unless you haveunderlying metabolic dysfunction, right? Hello! And then, if you have anunderlying autoimmune condition, you are also someone who's likely going tohave a not so positive response to these medications.What I love about mistletoe is it comes in and it modulates that teeter-totter. Itdoesn't take the breaks off and make it go hog wild, and it doesn't suppress. It's... kind of adaptogenic in some ways. So, it behaves a little bit like a smart drug,in that it can sort of match itself to the individual.It is not a protocol, it's a patient-driven process in that we look at the person'sgender, we look at the tumor type, the tumor stage, the general condition of thepatient, and then we consider the most appropriate host tree. The mostcommon are the pine, the fir, and the apple tree hosts. Mistletoe [from thesetrees] tends to have the highest lectin content that have the highest anti-cancercontent.Then we look at the dosing frequency, and if we're going to do it subcutaneous,intravenous, intratumoral, intraperitoneal, et cetera, depending on where youlive in the world and how we're going to pair it with other therapies, if at all. So,it is based totally on the individual and the individual's response.We want the patient to have a little local reaction if they're injecting it. We wantit to get a little redness, irritation and itchiness and maybe tenderness. We wantit to raise the body's temperature a little bit ... The point is, we want to createthis cytokine release at a very low-grade level. Whereas when we bring on animmune drug like Keytruda, it creates a cytokine release at an explosive levelthat can sometimes be fatal for patients.”

Other Mechanisms of Action and Synergies

Similar to drugs, mistletoe also has a systemic effect. It doesn't target a specific receptor site. Instead, it's a systemic terrain-centric approach. In its mechanisms of action, it's engaging with B-cells, T-cells, natural killer (NK) cells. It will basically calm those that are acting overzealous, to prevent an excessive immune reaction, and activate those that are dormant or underperforming. Mistletoe also reduces infiammation, lowering your levels of C-reactive protein, interleukin-6, homocysteine, liver enzymes and more. It also lowers vascular endothelial growth factor (VEGF), which can be important for certain cancers, and it lowers blood sugar and insulin. Winters also suspects mistletoe may be upregulating both the endorphin and the endocannabinoid system, so you're getting stress modulation as well.

“So, it's hitting all of what we call ‘The Terrain 10,' from my previous book, ‘TheMetabolic Approach to Cancer.' I find that mistletoe tends to hit every one ofthose ... including epigenetic expression ... clean up of DNA.We use it for people who've gone through radiation. We'll use it as a DNAstabilizer. We'll use it if people have taken a course of Cipro [and otherfiuoroquinolones] to help clean up the metabolic mayhem, the DNA damage thatthey cause. We know that it has some impact on insulin and IGF-1.In our book, we have hundreds of references to all of the different mechanismsof action. My colleague, Dr. Paul Faust, [has written] a beautiful chapter on itsdirect impact on the immune system and all the nuances of that.That chapter alone will illuminate for so many people why this therapeuticsupport and this therapeutic intervention is so helpful for the cancer patient, forprevention of cancer, for cleanup after cancer treatment ...And the synergy, when you pair mistletoe with hyperthermia, like so many of mycolleagues in Europe have been doing for the past 50 years, talk about thebiggest bang for your buck. We see some pretty extraordinary outcomes.I've had patients go to Europe with Stage 4 [cancer], metastatic diseaseeverywhere, getting IV mistletoe along with local, regional and whole body high-heat hyperthermia that have put their cancer into complete remission in manycases, but at the very least, turning it back into a manageable disease process,and even more interesting, increasing the responsivity to other therapies again.”

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