From ... in Biology — Oct 11, 2021

Ominous B1 Deficiency Found Throughout Food Chain

This article was previously published February 8, 2021, and has been updated with new information.Ominous B1 Deciency Found Throughout Food Chain Analysis by Dr.

. Joseph Mercola Fact Checked Vitamin B1 (thiamine) is used by nearly all your cells, metabolizing the carbohydrates and lipids in the foods you eat, helping to convert food into energy and boosting the ow of electrolytes in and out of your nerves and muscles Thiamine is important for healthy immune function, and may actually be crucial to protect against infectious respiratory illnesses such as COVID-19 While thiamine deciency is often the result of alcohol misuse, chronic infections, poor nutrition and/or malabsorption, recent research suggests vitamin B1 has dramatically declined throughout the food chain in recent years The transfer of thiamine up the food chain may be blocked by a number of factors, including the overabundance of thiaminase, an enzyme that destroys thiamine. Thiaminase is naturally present in certain microorganisms, plants and sh that have adapted to use it to their advantage Thiamine deciency has been identied in dozens of animal species and is now suspected of driving declines in wildlife populations across the northern hemisphere. This means our diets are likely to be low in thiamine, thereby raising the risk for thiamine deciency in the human population Vitamin B1 (thiamine) is used by nearly all your cells, and helps to metabolize the carbohydrates and lipids in the foods you eat. It also facilitates converting your food into energy and boosting the ow of electrolytes in and out of your nerves and muscles. It's considered "essential" because your body can't produce it on its own; it must come from an outside source. Thiamine is sometimes referred to as an "antistress" vitamin for its positive inuence on your central nervous system, and it's also important for healthy immune function. In addition to nutrients such as zinc and vitamins C and D, vitamin B1 (thiamine) may actually be crucial to protect against infectious respiratory illnesses such as COVID-19. Thiamine deciency syndrome (beriberi) has also been implicated in other types of severe infections and bears many similarities to sepsis. This is one of the reasons why thiamine is such an important part of Dr. Paul Marik's sepsis treatment. Sepsis, in turn, is a major contributor in inuenza deaths in general, and a primary cause for COVID-19 deaths specically. While thiamine deciency is often the result of alcohol misuse, chronic infections, poor nutrition and/or malabsorption, recent research suggests vitamin B1 availability has dramatically declined throughout the food chain in recent years. Lack of Thiamine Is Disrupting Ecosystem In a January 28, 2021, article in Hakai Magazine, Alastair Bland reviews ndings showing certain marine ecosystems are being decimated by an apparent lack of thiamine. Problems were noticed in January 2020 at salmon hatcheries in California. Fish were acting disoriented and mortality was surprisingly high. Initially, they feared a virus might be at play, but after digging through the medical literature, they found research discussing thiamine deciency in marine life. As noted in the article, vitamin B1 is "a basic building block of life critical to the functioning of cells and in converting food into energy." 1 2 3 Biologists tested the theory by dissolving thiamine powder into the water, and within hours, nearly all of the sh were acting normally again. Meanwhile, the behavior of sh in an untreated batch continued to decline. As a result of this research, many hatcheries took to applying thiamine, but the underlying problem still remains. "Since the sh acquire thiamine by ingesting it through their food, and females pass nutrients to their eggs, the troubling condition indicated that something was amiss in the Pacic Ocean, the last place the sh eat before entering fresh water to spawn," Bland writes, adding: "California researchers now investigating the source of the salmon's nutritional problems nd themselves contributing to an international effort to understand thiamine deciency, a disorder that seems to be on the rise in marine ecosystems across much of the planet. It's causing illness and death in birds, sh, invertebrates, and possibly mammals, leading scientists from Seattle to Scandinavia to suspect some unexplained process is compromising the foundation of the Earth's food web by depleting ecosystems of this critical nutrient." What's Causing Ecosystem-Wide Thiamine Deciency? As explained by Bland, "Thiamine originates in the lowest levels of the food web." Certain species of bacteria, phytoplankton, fungi and even some plants are responsible for synthesizing thiamine from other precursor compounds. From there, thiamine makes its way through both the animal and plant kingdoms. All organisms need it. In animals, enzymes interact with thiamine to generate cellular energy. Without sucient amounts of thiamine, fundamental metabolic processes start to fail, causing neurological disturbances, reproductive problems and increased mortality. While beriberi has been recognized as a serious health risk in humans for nearly 100 years, and thiamine supplementation has been standard practice for domesticated livestock such as sheep, cattle, mink and goats for several decades, the presence in and effect of thiamine deciency on wildlife wasn't discovered until the 1990s, when Canadian scientist John Fitzsimons started investigating the decline in Great Lakes trout. Bland writes: "Studying lake trout born in captivity, Fitzsimons observed symptoms like hyperexcitability, loss of equilibrium, and other abnormal behavior. He wondered if a nutritional deciency was at play, and to test for this he dissolved various vitamin tablets in water and using trout in different life stages, including fertilized eggs administered the solutions to the sh, both through injection and baths.

The idea was to see which vitamin, if any, cured the condition. 'It came down to a range of B vitamins, and it was only the thiamine that was able to reverse the signs I was seeing,' he says." Since the publication of Fitzsimons' ndings in 1995, thiamine deciency has been identied in dozens of animal species, including birds and moose. While severe deciency has lethal consequences, sublethal deciency can have insidiously devastating effects, including: Lowering strength and coordination Reducing fertility Impairing memory and causing other neurobehavioral decits. In humans, thiamine deciency has been shown to play a role in cases of delirium. In one study, 45% of cancer patients suffering from delirium had thiamine deciency, and 60% recovered when treated with intravenous thiamine Paralysis Loss of vocalization B1 Deciency May Be Responsible for Wildlife Declines 4 5 6 7 8 Thiamine deciency is now suspected of driving declines in wildlife populations all across the northern hemisphere. Bland cites research showing marine and terrestrial wildlife populations declined by half between 1970 and 2012. Between 1950 and 2010, the global seabird population declined by 70%. The transfer of thiamine up the food chain may be blocked by a number of factors, including overfishing. But there's yet another possibility, and that is the overabundance of thiaminase, an enzyme that destroys thiamine. Thiaminase is naturally present in certain microorganisms, plants and fish that have adapted to use it to their advantage. While habitat loss and other environmental factors are known to impact biodiversity, these declines are allegedly occurring far faster than can be explained by such factors. Researchers strongly suspect human involvement, but how? "Scientists are oating various explanations for what's depriving organisms of this nutrient, and some believe that changing environmental conditions, especially in the ocean, may be stiing thiamine production or its transfer between producers and the animals that eat them," Bland writes. "Sergio Saudo-Wilhelmy, a University of Southern California biogeochemist, says warming ocean water could be affecting the populations of microorganisms that produce thiamine and other vitamins, potentially upsetting basic chemical balances that marine ecosystems depend on. 'In different temperatures, different phytoplankton and bacteria grow faster,' he says. This, he explains, could hypothetically allow microorganisms that do not produce thiamine but, instead, acquire it through their diet to outcompete the thiamine producers, effectively reducing thiamine concentrations in the food web." 9 10 11 The transfer of thiamine up the food chain may be blocked by a number of factors, including overshing. But there's yet another possibility, and that is the overabundance of thiaminase, an enzyme that destroys thiamine. Thiaminase is naturally present in certain microorganisms, plants and sh that have adapted to use it to their advantage. "When larger animals eat prey containing thiaminase, the enzyme rapidly destroys thiamine and can lead to a nutritional deciency in the predator," Bland explains. One thiaminase-rich species is an invasive species of herring called alewife, which during the 20th century have spread through the Great Lakes, displacing native species. This, some researchers believe, has led to chronic and severe thiamine deciency in larger sh species. "The Great Lakes' saga illustrates the outsized impact that one single nutrient can have on an entire ecosystem," Bland writes. An overabundance of thiaminase-containing species also appears to be responsible for the decline in Sacramento River salmon. In this case, northern anchovy, which is rich in thiaminase, is the suspected culprit. Unfortunately, few answers have emerged as of yet. Giving thiamine to sh in hatcheries is not a long-lasting solution, because once they re-enter the wild, the deciency reemerges. One scientist likened the practice to "sending a kid with a fever off to school after giving them a Tylenol." Signs and Symptoms of Thiamine Deciency Considering both plants and wildlife are becoming increasingly thiamine-decient, it's logical to suspect that this deciency is becoming more common in the human population as well. Early symptoms of thiamine deciency include: Fatigue and muscle weakness Confusion and/or memory problems Loss of appetite and weight loss Numbness or tingling in arms or legs 12 13,14 As your deciency grows more severe, the deciency can progress into one of four types of beriberi: Paralytic or nervous beriberi (aka "dry beriberi") Damage or dysfunction of one or more nerves in your nervous system, resulting in numbness, tingling and/or exaggerated reexes Cardiac ("wet") beriberi Neurological and cardiovascular issues, including racing heart rate, enlarged heart, edema, breathing problems and heart failure Gastrointestinal beriberi Nausea, vomiting, abdominal pain and lactic acidosis Cerebral beriberi Wernicke's encephalopathy, cerebellar dysfunction causing abnormal eye movements, ataxia (lack of muscle coordination) and cognitive impairments. If left untreated, it can progress to Korsakoff's psychosis, a chronic brain disorder that presents as amnesia, confusion, short-term memory loss, confabulation (fabricated or misinterpreted memories) and in severe cases, seizures Thiamine is frequently recommended and given to people struggling with alcohol addiction, as alcohol consumption reduces absorption of the vitamin in your gastrointestinal tract. An estimated 80% of alcoholics are decient in thiamine and therefore more prone to the side effects and conditions above. Thiamine is also very important for those with autoimmune diseases such as inammatory bowel disease (IBD) and Hashimoto's (a thyroid autoimmune disorder). In case studies, thiamine supplementation has been shown to improve fatigue in autoimmune patients in just a few days. Interestingly, in one of these studies, which looked at patients with IBD, patients responded favorably to supplementation even though they all had "normal" baseline levels.

The authors speculate that thiamine deciency symptoms in such cases may be related to enzymatic defects or dysfunction of the thiamine transport mechanism (opposed to 15 16 17 18,19 20 being an absorption problem), which can be overcome by giving large quantities of thiamine. Thiamine in Infectious Disease As mentioned earlier, thiamine deciency has also been implicated in severe infections, including COVID-19. In fact, researchers have noted that, based on what we know about B vitamins' effects on the immune system, supplementation may be a useful adjunct to other COVID-19 prevention and treatment strategies. More generally, a 2016 study in the journal Psychosomatics sought to investigate the connection between thiamine and infectious disease by looking at 68 patients with Korsakoff syndrome. Thirty-ve of them suffered severe infections during the acute phase of the illness, including meningitis, pneumonia and sepsis, making the authors conclude that "Infections may be the presenting manifestation of thiamine deciency." Another study published in 2018 found thiamine helps limit Mycobacterium tuberculosis (MTB) by regulating your innate immunity. According to this paper: " vitamin B1 promotes the protective immune response to limit the survival of MTB within macrophages and in vivo Vitamin B1 promotes macrophage polarization into classically activated phenotypes with strong microbicidal activity and enhanced tumor necrosis factor- and interleukin-6 expression at least in part by promoting nuclear factor-B signaling. In addition, vitamin B1increases mitochondrial respiration and lipid metabolism Our data demonstrate important functions of thiamineVB1 in regulating innate immune responses against MTB and reveal novel mechanisms by which vitamin B1 exerts its function in macrophages." Thiamine deciency is also associated with the development of high fever, and according to a letter to the editor, "Is Parenteral Thiamin a Super Antibiotic?" published 21 22 23 in the Annals of Nutrition & Metabolism in 2018, thiamine injections are "likely to eradicate microbial infections" causing the fever. By dramatically increasing susceptibility to infections, thiamine deciency could potentially have the ability to impact the spread of just about any pandemic infectious disease including COVID-19. Are You Getting Enough B Vitamins? While biologists struggle to nd an ecosystem-wide solution for thiamine deciency in the food chain, the solution for us, in the meantime, may be to make sure we get enough thiamine through supplementation. Evidence suggests thiamine insuciency or deciency can develop in as little as two weeks, as its half-life in your body is only nine to 18 days. Ideally, you can select a high-quality food-based supplement containing a broad spectrum of B vitamins to avoid creating an imbalance.

The following guidelines will also help protect or improve your thiamine status: Limit your sugar and rened grain intake As noted by the World Health Organization, "Thiamine deciency occurs where the diet consists mainly of milled white cereals, including polished rice, and wheat our, all very poor sources of thiamine." Simple carbs also have antithiaminergic properties, and raise your thiamine requirement for the simple fact that thiamin is used up in the metabolism of glucose. Eat fermented foods The entire B group vitamin series is produced within your gut provided you have a healthy gut microbiome. Eating real food, ideally organic, along with fermented foods will provide your microbiome with important ber and benecial bacteria to help optimize your internal vitamin B production as well. 24 25 26 Avoid excessive alcohol consumption, as alcohol inhibits thiamine absorption, and frequent use of diuretics, as they will cause thiamine-loss. Avoid sulte-rich foods and beverages such as nonorganic processed meats, wine and lager, as sultes have antithiamine effects. Correct any suspected magnesium insuciency or deciency, as magnesium is required as a cofactor in the conversion of thiamine. Daily Intake Recommendations While individual requirements can vary widely, the typical daily intake recommendations for B vitamins are as follows: Nutrient Supplement Recommendations Thiamine (B1) Adult men and women need 1.2 and 1.1 mg respectively each day. If you have symptoms of thiamine deciency, you may need higher doses. Thiamine is water-soluble and nontoxic, even at very high doses, so you're unlikely to do harm. Doses between 3 grams and 8 grams per day have been used in the treatment of Alzheimer's without ill effect. Riboavin (B2) Suggested daily intake is about 1.1 mg for women and 1.3 mg for men. 27 28 Nutrient Supplement Recommendations Niacin (B3) The dietary reference intake established by the Food and Nutrition Board ranges from 14 to 18 mg per day for adults. Higher amounts are recommended depending on your condition. For a list of recommended dosages, see the Mayo Clinic's website. Vitamin B6 Nutritional yeast (not to be confused with Brewer's yeast or other active yeasts) is an excellent source of B vitamins, especially B6. One serving (2 tablespoons) contains nearly 10 mg of vitamin B6, and the daily recommended intake is only 1.3 mg. B8 (inositol/biotin) B8 is not recognized as an essential nutrient and no recommended daily intake has been set. That said, it's believed you need about 30 mcg per day. Vitamin B8 is sometimes listed as biotin on supplements. Brewer's yeast is a natural supplemental source. 29 30 31 32 33 Nutrient Supplement Recommendations Folate (B9) Folic acid is a synthetic type of B vitamin used in supplements; folate is the natural form found in foods. (Think: Folate comes from foliage, edible leafy plants.) For folic acid to be of use, it must rst be activated into its biologically active form (L-5-MTHF). This is the form able to cross the blood- brain barrier to give you the brain benets noted. Nearly half the population has diculty converting folic acid into the bioactive form due to a genetic reduction in enzyme activity. For this reason, if you take a B-vitamin supplement, make sure it contains natural folate rather than synthetic folic acid. Nutritional yeast is an excellent source. Adults need about 400 mcg of folate per day. 34 35 Nutrient Supplement Recommendations Vitamin B12 Nutritional yeast seasoning is also high in B12, and is highly recommended for vegetarians and vegans. One serving (2 tablespoons) provides about 67 mcg of natural vitamin B12. Sublingual (under-the-tongue) ne mist spray or vitamin B12 injections are also effective, as they allow the large B12 molecule to be absorbed directly into your bloodstream. Sources and References Chest June 2017; 151(6): 1229-1238 The Science Times January 31, 2021 Hakai Magazine January 28, 2021 Los Angeles Times January 26, 2021 Brain Sciences August 2020; 10(8): 565 EJCN January 29, 2021 Scientic Reports 2016; 6 Article number 38821 alcoholrehabhelp.org Thiamine Healthline May 18, 2018 Thyroidpharmacist.com February 3, 2015 Journal of Alternative and Complementary Medicine 2013 Aug;19(8):704-8 Journal of Alternative and Complementary Medicine 2013; 00(00): 1-4 (PDF) Psychosomatics Nov-Dec 2016; 57(6): 624-633 Frontiers in Immunology 2018; 9(1778) Annals of Nutrition & Metabolism 2018;72:149150, Letter to the Editor Journal of Thoracic Disease 2016 Jun; 8(6): 10621066, Thiamine Elimination and Associated Thiamine Insuciency Syndromes WHO.int Thiamine Deciency and Its Prevention and Control in Major Emergencies (PDF) Nutrition Journal February 10, 2005; 4:7 NIH Thiamine June 3, 2020 NIH Riboavin January 6, 2021 36 1 2 3, 5, 6, 10, 11, 12 4 7 8 9 13, 15, 16 14 17 18, 20 19 21 22 23 24 25 26 27 28 Mayo Clinic Niacin Dosing Self Nutrition Data, Nutritional Yeast NIH Vitamin B6 February 24, 2020 NIH Biotin June 3, 2020 Mount Sinai Health 2021 Chalkboard, Nutritional Yeast NIH Folate July 11, 2019 USDA Nutritional Yeast Seasoning July 17, 2019 29 30 31 32 33 34 35 36 .

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