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Biology

A collection of 1231 articles

Pharmacologic inhibition of Dipeptidyl peptidase 1 (Cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells

Recently developed small molecule inhibitors of the lysosomal protease dipeptidyl peptidase 1 (DPP1), also known as cathepsin C (CatC), can suppress suppurative inflammation in vivo by blocking the processing of zymogenic (pro-) forms of the neutrophil serine proteases (NSPs), including neutrophil elastase, proteinase 3, and cathepsin G. However, DPP1 also

Expression and clinical significance of interleukin-6 pathway in cholangiocarcinoma

Background: Cholangiocarcinoma (CCA) is a typical inflammation-induced malignancy, and elevated serum interleukin-6 (IL-6) levels have been reported to be linked to the onset and progression of CCA.

Effect of blueberry intervention on endothelial function: A systematic review and meta-analysis

Endothelial dysfunction indicates blood vessel injury and is a risk factor for cardiovascular diseases.

Chronic Pain Due to Mitochondrial Dysfunction, Niacinamide Can Treat It

About 21% of U.S.

Mother’s Day Poetry: Las Tradiciones

To honor ourselves, we must first learn to honor our mothers, grandmothers, and every ancestor before them.We do not realize how much we accept from them until they are gone.

Genome-wide identification of bZIP transcription factors and their expression analysis in Platycodon grandiflorus under abiotic stress

The Basic Leucine Zipper (bZIP) transcription factors (TFs) family is among of the largest and most diverse gene families found in plant species, and members of the bZIP TFs family perform important functions in plant developmental processes and stress response. To date, bZIP genes in Platycodon grandiflorus have not been

Class I TCP in fruit development: much more than growth

Fruit development can be viewed as the succession of three main steps consisting of the fruit initiation, growth and ripening.

Identification of male-fertility gene AsaNRF1 and molecular marker development in cultivated garlic (Allium sativum L.)

Garlic cultivars are predominantly characterized by their sterility and reliance on asexual reproduction, which have traditionally prevented the use of hybrid breeding for cultivar improvement in garlic. Our investigation has revealed a notable exception in the garlic line G398, which demonstrates the ability to produce fertile pollen. Notably, at the

LexA, an SOS response repressor, activates TGase synthesis in Streptomyces mobaraensis

Transglutaminase (EC 2.3.2.13, TGase), an enzyme that catalyzes the formation of covalent cross-links between protein or peptide molecules, plays a critical role in commercial food processing, medicine, and textiles. TGase from Streptomyces is the sole commercial enzyme preparation for cross-linking proteins. In this study, we revealed that

How Ultraprocessed Foods Are Slowly Killing Us

Consumption of ultraprocessed foods in the U.S.

Dissolving Illusions About Vaccine Safety

In this interview, Dr.

How Light Exposure Plays a Role in Cognition

Can bright light exposure lead to a sharper mind and heightened alertness? Researchers from the University of Liège in Belgium sought out the answer to this.

Placental co-transcriptional activator Vestigial-like 1 (VGLL1) drives tumorigenesis via increasing transcription of proliferation and invasion genes

Vestigial-like 1 (VGLL1) is a co-transcriptional activator that binds to TEA domain-containing transcription factors (TEADs).

An optimized method for IgE-mediated degranulation of human lung mast cells

Background: Mast cells are critically involved in IgE-mediated diseases, e.g., allergies and asthma.

Ferroptosis and hepatocellular carcinoma: The emerging role of lncRNAs

Hepatocellular carcinoma is the most common form of primary liver cancer and poses a significant challenge to the medical community because of its high mortality rate.