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Biology

A collection of 1232 articles

The bispecific B7H3xCD3 antibody CC-3 induces T cell immunity against bone and soft tissue sarcomas

Sarcomas are rare and heterogeneous malignancies that are difficult to treat.Approximately 50% of patients diagnosed with sarcoma develop metastatic disease with so far very limited treatment options.

Retinal microglia express more MHC class I and promote greater T-cell driven inflammation than brain microglia

Macrophage function is determined by microenvironment and origin.Brain and retinal microglia are both derived from yolk sac progenitors, yet their microenvironments differ.

How Your Microbiome Influences Your Dietary Recommendations

In the ever-evolving ﬁeld of bioenergetic medicine, the relationship between our diet, microbiome, and overall health continues to unveil complex and intriguing connections.

Bronchom assuages airway hyperresponsiveness in house dust mite-induced mouse model of allergic asthma and moderates goblet cell metaplasia, sub-epithelial fibrosis along with changes in Th2 cytokines and chemokines

Background: Asthma is a common obstructive airway disease with an inflammatory etiology.

Joint transcriptomic and metabolomic analysis provides new insights into drought resistance in watermelon (Citrullus lanatus)

Introduction: Watermelon is an annual vine of the family Cucurbitaceae.Watermelon plants produce a fruit that people love and have important nutritional and economic value.

Preclinical characterization of a novel investigational monoclonal antibody CM313 with potent CD38-positive cell killing activity

Introduction: CM313 is currently under clinical investigation for treatments of multiple myeloma, systemic lupus erythematosus, and immune thrombocytopenia.

Functional identification of DNA demethylase gene CaROS1 in pepper (Capsicum annuum L.) involved in salt stress

Pepper, which is a widely cultivated important vegetable, is sensitive to salt stress, and the continuous intensification of soil salinization has affected pepper production worldwide.

A case report of IgG4-related hepatic inflammatory pseudotumor in a 3-year old boy

Background: Hepatic Inflammatory Pseudotumor (IPT) is an infrequent condition often masquerading as a malignant tumor, resulting in misdiagnosis and unnecessary surgical resection.

Shock Study Finds E-Cigarettes May Raise Risk of Heart Failure

It's a myth that electronic cigarettes (e-cigarettes) are safer for your health than regular cigarettes.

SSRI Drugs Can Cause Chronic Fatigue Syndrome

Serotonin — also known as 5-hydroxytryptamine or 5-HT — is typically referred to as “the happiness hormone” and deﬁciency is thought to be the source of depression.

Plasma proteomics analysis of Chinese HIV-1 infected individuals focusing on the immune and inflammatory factors afford insight into the viral control mechanism

Background: Long-term non-progressors (LTNPs) with HIV infection can naturally control viral replication for up to a decade without antiretroviral therapy (ART), but the underlying mechanisms of this phenomenon remain elusive. Methods: To investigate the relevant immune and inflammatory factors associated with this natural control mechanism, we collected plasma samples from

Autoimmune uveitis attenuated in diabetic mice through imbalance of Th1/Th17 differentiation via suppression of AP-1 signaling pathway in Th cells

Inflammation is involved in the pathogenesis of diabetes, however the impact of diabetes on organ-specific autoimmune diseases remains unexplored.Experimental autoimmune uveoretinitis (EAU) is a widely accepted animal model of human endogenous uveitis. In this study, we investigated the effects of diabetic conditions on the development of EAU using a

Inhibition of interferon gamma impairs induction of experimental epidermolysis bullosa acquisita

Epidermolysis bullosa acquisita (EBA) is a muco-cutaneous autoimmune disease characterized and caused by autoantibodies targeting type VII collagen (COL7).

Anti-inflammatory and/or immunomodulatory activities of Uncaria tomentosa (cat's claw) extracts: a systematic review and meta-analysis of in vivo studies

Background: Uncaria tomentosa (Willd.ex Schult.) DC.(Rubiaceae), is traditionally used by Amazonian indigenous groups to treat inflammatory diseases.

Fascinating Research on Vitamin A From 1925

My colleague Pam Schoenfeld, MS, recently put me onto an eye-opening article on vitamin A.