Topic

Biology

A collection of 1139 articles

Network analysis combined with experimental assessment to explore the therapeutic mechanisms of new shenqi pills formula targeting mitochondria on senile diabetes mellitus

The objective of this study was to investigate the mechanisms of action of SQP in the treatment of SDM and make an experimental assessment.Methods: Network analysis is used to evaluate target pathways related to SQP and SDM. Mitochondrial-related genes were obtained and intersected with the common target genes of

Pharmacologic inhibition of Dipeptidyl peptidase 1 (Cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells

Recently developed small molecule inhibitors of the lysosomal protease dipeptidyl peptidase 1 (DPP1), also known as cathepsin C (CatC), can suppress suppurative inflammation in vivo by blocking the processing of zymogenic (pro-) forms of the neutrophil serine proteases (NSPs), including neutrophil elastase, proteinase 3, and cathepsin G. However, DPP1 also

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