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The Benefits of Curcumin in Tumor Treatments

STORY AT-A-GLANCE Editor's Note: This article is a reprint.

The Benefits of Curcumin in Tumor Treatments

It was originally published March 2, 2014. Cancer is one of the leading causes of death. What if there were a safe, natural herb that could work for nearly every type of cancer? According to Dr. William LaValley, who focuses most of his clinical work on the treatment of cancer, curcumin — a derivative of turmeric and the pigment that gives the curry spice turmeric its yellow-orange color — may fit the bill. It's a natural compound that has been extensively researched, and has been found to have numerous health applications. Like me, LaValley was trained in general medicine, but he's devoted a considerable amount of time to understanding the biochemical pathways that can support health

nutritionally. In 1982, he participated in an exchange program to the People's Republic of China, where he got first-hand experience with the ancient practices of traditional Chinese medicine and acupuncture.

"One of the important messages that I learned there was that natural products,natural molecules, from plants and animals that are already available in nature,have been used by the Chinese for at least hundreds, probably thousands ofyears. That deeply changed my perspective in the world of medicine,"

he says.

"I came back to medical school, and thereafter, looked at how I could integratethe perspective of conventional pharmaceutical administration as well asnatural extract, natural product administration."

Curcumin Has Potent Anticancer Activity

In 2005, he took a 75% sabbatical from clinical practice to immerse himself in the science of molecular biology, specifically the molecular biology of cancer. He also devoted approximately 9,000 to 9,500 hours building a relational database from the PubMed literature about the molecular biology of cancer. One important lesson he learned through that venture is that the understanding of molecular biology can be applied across a range of diseases and symptoms described in the scientific literature. That knowledge can be applied by searching PubMed and other related databases, looking at the relevant molecular pathways involved.

"In learning the molecular biology of cancer pathways, and in learning that whatthe evidence actually shows for the effect of natural product extracts on variousrelevant molecular targets in various cancers, we see that there's actually quitea large amount of evidence that supports using various molecules, naturalproducts, and pharmaceuticals that are already approved and that have beenaround for a long time to affect anti-cancer activity along that pathway at thattarget.That's called molecularly targeted anti-cancer treatment, and it's widelypracticed in oncology today.What's not widely practiced is the use of the natural products for themolecularly targeted anticancer activity. I provide that for my patients becausethe evidence base suggests and supports the use of these treatmentrecommendations."

Curcumin — A 'Universal' Cancer Treatment?

Interestingly, curcumin appears to be universally useful for just about every type of cancer, which is really odd since cancer consists of a wide variety of different molecular pathologies. You wouldn't necessarily suspect that there would be one herb that would work for most of them. LaValley explains how he came to this conclusion:

"I went back to the literature and looked at how I can support the decision-making process and the recommendations that I'm making for treatment fromthe scientific literature, including literature that goes from the treatment ofhumans with oral products like pharmaceuticals or natural products.This is where I learned about this molecule called curcumin, all the way down toits use in animals and then its use in test tubes or petri dish … One of theamazing things about curcumin is that this molecule has some profound anti-infiammatory activity and has activity in many molecular targets.There are molecules that are in the cells, and those molecules interact witheach other along certain pathways or tracks. The trafic of that interaction, thesignals that are transferred in that traficking of information in the molecules,presents many different targets or molecular-specific complexes."

As explained by LaValley, whether the curcumin molecule causes an increase in trafic or activity of a particular molecular target, or a decrease/inhibition of activity, studies repeatedly show that the end result is a potent anticancer activity. Furthermore, curcumin does not adversely affect healthy cells, suggesting it selectively targets


cancer cells. Research has also shown that it works synergistically with certain chemotherapy drugs, enhancing the elimination of cancer cells.

Curcumin Destroys Cancer in Multiple Ways

Curcumin has the most evidence-based literature supporting its use against cancer of any nutrient, including vitamin D, which also has a robust base. Interestingly, this also includes the metabolite of curcumin and its derivatives, which are also anticancerous. Curcumin has the ability to modulate genetic activity and expression — both by destroying cancer cells and by promoting healthy cell function. It also promotes anti- angiogenesis, meaning it helps prevent the development of additional blood supply necessary for cancer cell growth. As for its effect on molecular pathways, curcumin can affect more than 100 of them, once it gets into the cell. More specifically, curcumin has been found to: Inhibit the proliferation of tumor cells Decrease infiammation Inhibit the transformation of cells from normal to tumor Inhibit the synthesis of a protein thought to be instrumental in tumor formation Help your body destroy mutated cancer cells so they cannot spread throughout your body Help prevent the development of additional blood supply necessary for cancer cell growth (angiogenesis)

Why Whole Turmeric Is Ineffective

Unfortunately, while there's some curcumin in whole turmeric , there's not enough in the regular spice to achieve clinically relevant results. The turmeric root itself contains only about 3% curcumin concentration. Another major limitation of curcumin as a therapeutic agent is that it is poorly absorbed. When taken in its raw form, you're only absorbing about 1% of the available curcumin.

"The natural product industry has developed a standard of a 95% concentrationof curcumin,"

LaValley explains.

"Initially, years ago, that was what we hadavailable for patients. Even at that, taking a 95% concentration orally in acapsule, only 1% of that could be absorbed. In order to get amounts of curcuminin the bloodstream that are reasonable to have therapeutic effect, people had totake large amounts of curcumin …In searching the literature, I found that a way to change that, to dramaticallyincrease the bioavailability, is actually a very simple process of bringing waterto a boil, putting those capsules or some dry powder (I use it by the teaspoon),and boiling it for 10 to 12 minutes. That increases the amount of curcumindissolved in water from that 1% amount up to 12% or so.That amount is a vast number of curcumin molecules that are now in abioavailable or absorbable form."

However, while this is certainly doable, it's really inconvenient, and great care must be taken to prevent staining your clothes and kitchen surfaces. It's a significant enough problem to have been dubbed "yellow kitchen syndrome," as it's virtually impossible to get the stains out. Turmeric is in fact an excellent dyeing agent for fabrics, rendering them a yellow-orange color. Convenience and eficiency has driven many of the changes in the forms of curcumin in later years. Because it's a fat-loving or lipophilic molecule, many newer preparations now include some sort of oil or fat, which improves its absorbability and bioavailability. Such preparations typically have seven to eight times higher absorption than the raw, unprocessed 95% concentration of dry powder. There are also newer sustained release preparations, which LaValley prefers and recommends.

The Connection Between Cancer and Insulin Resistance

If you are overweight, or have high blood pressure, high cholesterol, and/or diabetes, then in all likelihood insulin and leptin resistance is a factor. Insulin and leptin resistance is also a very common factor among cancer patients. From my perspective, a ketogenic diet (with or without intermittent fasting) would be a prudent treatment strategy to resolve that underlying problem. Once you've normalized your insulin and leptin, you don't necessarily need to maintain a ketogenic diet , if you find it too restrictive.

"I agree with you that a ketogenic diet is really appropriate in many cases,probably the significant majority of cases,"

LaValley says.

"It's been known forprobably 80 years or longer that solid tumors, and some of the blood cancers,are sugar-loving. Another term is that they are addicted to sugar.I use [a] PET scan to demonstrate to patients that here is objective proof thatthe tumors you have in your body are sugar-avid. They're taking up sugar at arate much higher than the other regular healthy cells. I want to drive home thatmessage, so that they are motivated to alter their diet to have a low, low carbintake, causing their body to generate additional nutrient supply moleculescalled ketones …What that means is that we're trying to provide an anticancer antagonisticpressure on the cancer cells by reducing the amount of sugar that's readilyavailable for uptake by reducing the easily available sugar in the diet andcompensating for the nutrient reduction and sugar [reduction] by increasinghealthy fats."

Cutting Down on Protein May Be Useful for Cancer Patients

It would also be prudent to assess your protein intake. Many Americans eat far more protein than required for optimal health. The reason for this is because your body can actually use excess protein to stimulate carbohydrate production. Excess protein also stimulates the mammalian target of rapamycin (mTOR) pathways, which are useful for building muscles but can be detrimental when treating cancer, as mTOR is a pathway that increases cellular proliferation. (Interestingly, the pharmaceutical drug metformin, which has anticancer activity, also inhibits mTOR, and it turns out that curcumin has a very similar effect.) The formula I recommend for assessing how much protein you might need in your diet is from nutritionist Dr. Ron Rosedale, which calls for 1 gram of high-quality protein per kilogram of lean body mass, or about half a gram per pound of lean body mass. As an example, if your body fat mass is 20%, your lean mass is 80% of your total body weight. So, if your total weight is 200 pounds; you would then divide 160 by 2.2 to convert pounds to kilograms and come up with 72.7 grams of protein. If you are doing vigorous exercises or are pregnant, you can add up to another 25% or another 18 grams in this illustration to increase your total to 90 grams per day.

More Information

LaValley is available for consultation on a wide variety of health challenges, including cancer, and he's licensed to practice medicine in the U.S. and Canada. His medical clinic is located in Chester, Nova Scotia, where he sees patients. Americans can fiy there either through Chicago or Newark. His ofice number in Canada is 902-275-4555. In the U.S. it's 512-794-8907. He also spends time in Austin, Texas, where he conducts research. When there, he's available to consult for other physicians and their patients. He currently is completing a book explaining the science and benefits of molecular integrative oncology (what he calls "the other half of cancer treatment"), to be published in 2023.

"For instance, if a patient has pancreatic cancer and the physician wants toimplement one of the protocols that I provide, I will do a consultation with thatphysician's patient and then make recommendations to that physician forimplementation,"

he explains.

"In that way, patients are able to get it locallywithout having to travel to Nova Scotia …It's a challenge right now because there's so much information that's not readilyknown by so many physicians that they become afraid. I think one of thebiggest issues, certainly in U.S. and Canada, is that when a physician wants toadminister one of these natural products, or several of them, as well as some ofthe off-label pharmaceuticals for their anti-cancer usage, they are afraid ofrecriminations or disciplinary actions.That is, I think, very unfortunate, because the evidence base does exist for it,and it's consistent with the way that other types of conventional medicine orpractice using off-label pharmaceuticals as well.I think that the most important movement that needs to occur is for the patientsto recognize their own value in the decision-making process and demand thatthey have access to these therapeutic choices because they're available, they'resupported in the evidence base, and they have the right to ask for them ratherthan to just accept whatever the physician is otherwise offering in theconventional realm."

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