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Turns Out, Ebola Likely Leaked From a Lab as Well

STORY AT-A-GLANCE In December 2013, Zaire Ebola hemorrhagic fever broke out in Guinea and over the next three years spread across West Africa, ultimately killing 11,323 people.

Turns Out, Ebola Likely Leaked From a Lab as Well

While Ebola epidemics occur on a near-annual basis, this was the largest and deadliest in history.

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Of the five Ebola viruses known to cause disease in humans, Zaire Ebolavirus, first identified in Zaire in 1976, is the most dangerous, with a fatality rate ranging between 53% and 88%, depending on the variant. The virus leads to severe immunosuppression, but most deaths are attributed to dehydration caused by gastric problems. Early signs of infection include nonspecific fiu- like symptoms and sudden onset of fever, diarrhea, headache, muscle pain, vomiting and abdominal pains. Other less common symptoms include sore throat, rashes and internal/external bleeding. As the infection sets in, shock, cerebral edema (fiuid on the brain), coagulation disorders and secondary bacterial infections may occur. Hemorrhaging tends to begin four to five days after onset of the initial symptoms, which includes bleeding in the throat, gums, lips and vagina. Vomiting blood, excreting tar-like feces indicative of gastrointestinal bleeding, and liver- and/or multi-organ failure can also occur.

The Virus Hunter That Assigned Zoonotic Origin

According to a paper published at the end of December 2014, the Ebola epidemic was traced back to a 2-year-old boy in Meliandou, Guinea, named Emile Ouamouno. Supposedly, the boy had come in contact with an infected fruit bat in a hollowed-out tree. This, even though no Ebolavirus RNA was ever detected in any of the bat samples collected from the area. Interestingly enough, the senior author on that paper was Fabian Leendertz, a renowned virus hunter with the Robert Koch Institute in Germany. Leendertz was also a member of the World Health Organization team that investigated the origin of COVID-19. As you may recall, they also concluded, without evidence, that SARS-CoV-2 was most likely of zoonotic origin and dismissed the lab leak theory as not worthy of further consideration.

Lab Leak Suspected From the Start

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However, just as with SARS-CoV-2, suspicions and rumors that the Ebola outbreak was the result of a lab leak were present from the start. Some scientists even suspected the virus might be a weaponized form of Ebola. As noted in a 2014 paper in the Journal of Molecular Biochemistry:

"Another subject that may cause a plethora of arguments is that this virus maybe a laboratory generated virus … There is a conjecture that the virus istransmitted to people from wild animals. However, by reason of the highmortality among them, it is impossible that these animals are the reservoir hostof EVD."

In late October 2022, Sam Husseini and Jonathan Latham, Ph.D., published a new analysis in Independent Science News, in which they laid out the evidence pointing to a lab leak. They also dissect Leendertz December 2014 report, highlighting the holes in the zoonotic origin narrative. In fact, there's evidence to suggest the outbreak in in Meliandou wasn't Ebola at all. Husseini and Latham write:

"Chernoh Bah, an independent journalist from Sierra Leone, wrote a book on the2014 Ebola outbreak and visited Meliandou. Bah found that: 'Local healthworkers still think malaria may have been the actual cause of his [Emile's]death.'While in Meliandou, Chernoh Bah also interviewed Emile's father. According toBah, the Leendertz team (who never claimed to have interviewed the father)made a crucial error: 'The child was actually 18 months old when he died' … Theage question, it should be noted, is crucial to the entire outbreak narrative. AsEmile's father told Reuters:'Emile was too young to eat bats, and he was too small to be playing in the bushall on his own. He was always with his mother.' Bah also identified anotherapparent error: that Emile had four siblings who never became sick. Thesesiblings are not mentioned anywhere in the scientific literature …
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Further, although some bats appear to carry antibodies against Ebola viruses,only intact Bombali Ebola (a different virus species in the Ebola genus) has everbeen isolated from a bat, despite intensive searches … Bombali is a species ofEbola that does not infect humans.Taken together, this suggests that bats rarely carry Ebola viruses and when theydo it is in small quantities. This context makes it somewhat surprising that Saézet al. ascribed the 2014 outbreak (without supporting evidence) to contact withbats.Indeed, Fabian Leendertz now doubts that bats are true reservoirs of Ebolaviruses. Given the general want of evidence, one wonders by what exactprocess such poorly supported claims were transmuted into internationalheadlines."

Was Ebola Experimented On Before the Outbreak?

As detailed by Husseini and Latham, "persistent rumors in the region linked the outbreak to a US-run research laboratory in Kenema, Sierra Leone. This facility studies viral hemorrhagic diseases, of which Ebola is one." The Kenema lab, which has been run by the U.S.-based Viral Hemorrhagic Fever Consortium (VHFC) since 2010, is located about 50 miles from the village in Guinea where the Ebola outbreak first emerged. The founder and president of the VHFC is Robert (Bob) Garry, who was also part of the group of virologists who in the earliest days of the COVID-19 pandemic concocted "The Proximal Origin of SARS-CoV-2" paper in which they dismissed the lab leak theory and insisted zoonotic origin was the most plausible, despite the lack of evidence. As recently as November 2022, Garry still insisted SARS-CoV-2 "emerged via the wildlife trade." In that same article, Garry drew parallels to the 2014 Ebola outbreak, claiming that conspiracy pundits were wrong about Ebola being leaked from the Kenema lab,

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because "we did not have EBOV [ebolavirus] in our laboratory and therefore could not have released or engineered it." According to Garry, the Ebola and SARS-CoV-2 outbreaks are both victims of "guilt-by- proximity." However, in a March 11, 2023, interview on the Decoding the Gurus podcast, Kristian Andersen, vice president of the VHFC's Kenema lab and another "Proximal Origin" author, clearly refuted Garry's claim:

"The problem is that people see these coincidences. One of the new ones is theEbola lab leak, which also is being blamed on us, because we had been studyingEbola in Kenema in Sierra Leone, and lo and behold Ebola emerged just a fewmiles from there in 2014,"

Andersen said. So, what do we make of this? Garry claims the Kenema lab didn't have any Ebola virus and Andersen says they did. Both are top executives at the lab and ought to know what was studied and what wasn't. So, who's telling the truth?

Was Kenema Lab Involved in Biowarfare Work?

According to Husseini and Latham, there's good reason to believe the Kenema lab was working with Ebola before the outbreak in Guinea, some 50 miles from the lab. For starters, the Guinea outbreak was the first time Zaire Ebola emerged in West Africa. All previous outbreaks of this most-lethal strain of Ebola occurred in the Congo basin, in the central African equatorial zone, some 3,000 kilometers (approximately 1,864 miles) from Guinea. "Hence Zaire Ebola's appearance in West Africa was a striking and very unexpected development," they write. How did it get there? Ebola is not highly contagious as transmission typically requires direct contact. There were no outbreaks between the Congo basin and Guinea, which you'd expect if it was spreading naturally from person to person. Equally mysterious is the fact that genome sequencing and phylogenetic analysis showed only a single jump from animal to human. Husseini and Latham explain:

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"Zoonotic outbreaks, including most past Ebola outbreaks, typically featuremultiple jumps to humans from an animal source. Single jumps, however, areconsistent with lab origins and are often considered a red fiag for thatpossibility.The reason is that researchers often work with a single isolate, perhaps onethat they have found is particularly easy to replicate in the laboratory, whereasnatural populations are typically diverse. This difference provides a geneticsignal for distinguishing natural origins from laboratory ones."

Zaire Ebola is also the preferred species used by research labs studying Ebola-type viruses, as it's the most lethal and therefore has the greatest biowarfare potential. Husseini and Latham continue:

"Noting the gap between the weakness of the Leendertz account of theoutbreak origin … and the forcefulness with which the Emile narrative wasasserted by western scientists and western media, [journalist Chernoh Bah]wrote:'it is dificult not to interpret the 'zoonotic origin of the West African Ebolaepidemic' narrative advanced by Fabian Leendertz and his team as part of acover-up or obfuscation of the actual chain of events that laid the foundationfor the West African Ebola outbreak' …In 2011, three years before the West African Ebola outbreak, Reuters profiledthe research in Kenema at length. Readers were told that a 'laboratory insoutheastern Sierra Leone is an outpost of the U.S. government's 'war on terror,'funded by a surge in bio-defense spending … [By] the fiscal year 2007 the NIHwas requesting more than $1.9 billion.' Reuters concluded that the Kenema labs'share of that allocation was $40 million.On August 25, 2013, just months before the Ebola outbreak, the VHFC postedon its website an article titled: 'Researchers at the Scripps Research Institute
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make major advances in the fight against Ebola virus.' This article was laterremoved but its existence is verifiable using the WayBackMachine.Nevertheless, the title alone raises some key questions: Why did the VHFC postabout Ebola if it wasn't working on it at the time? In particular, what Ebolavariant was being studied? What was the nature of the experiments? Whyremove the post? …We do know that Ebola was important to the VHFC and its partners and aprimary interest for at least some of its members.Indeed, all the leading US-based researchers of the VHFC, Robert Garry, KristianAndersen, Erica Ollmann Saphire and Pardis Sabeti have published multipleoriginal research papers on Ebola virus.

An Ebola focus also accords

with US biosecurity research priorities under whose auspices the Kenema lab islargely funded …In 2013 Robert Garry co-authored a paper on a novel treatment for ZaireEbola. All eleven other authors were from USAMRIID, aka Fort Detrick. This siteis the largest 'biodefense' facility in the world and Garry's company, Zalgen, islocated close-by."

More Biowarfare Connections and Ebola Trials

Husseini and Latham point out that in 2014, when the Ebola outbreak occurred, Metabiota was a VHFC partner. As detailed in " Evidence of Pandemic and Bioweapon Cover-Ups ," Metabiota was hired by the WHO and the local government of Sierra Leone to monitor the spread of the Ebola epidemic, but clearly were not up to the task. A 2016 CBS News report detailed Metabiota's bungled response. 2014 was also the year when Metabiota was entrusted with the operations of U.S. biological research labs in Ukraine, with funding from the Defense Threat Reduction Agency (DTRA) and:

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Pilot Growth Management, cofounded by Neil Callahan. Callahan is also a cofounder of Rosemont Seneca Technology Partners, and he sits on Metabiota's board of advisers In-Q-Tel, a CIA venture capital firm that specializes in high-tech investments that support or benefit the intelligence capacity of U.S. intelligence agencies Rosemont Seneca, an investment fund co-managed by Hunter Biden Metabiota's founder, Nathan Wolfe, is also tied to EcoHealth president Peter Daszak, Ph.D., a prime suspect in the COVID pandemic who worked closely with the Wuhan Institute of Virology (WIV) in China, where SARS-CoV-2 is suspected of having originated. Wolfe has also received more than $20 million in research grants from Google, the NIH and the Bill & Melinda Gates Foundation, just to name a few.

Of all the scientists, companies and organizationsinvolved in this kind of research across the world, howis it that the same short list of names pop up both inthe Guinea Ebola case and COVID-19?

Aside from the Kenema lab's obvious biowarfare connections, and the possibility of Ebola being experimented on there, several Ebola treatment trials were also taking place in Port Loko, Sierra Leone, about 190 km (118 miles) from Kenema, right around the same time that Ebola broke out in Guinea.

"From the limited descriptions available, one of these trials fits the timingrequired for it to have triggered the 2014 Ebola outbreak but none of them fitsthe location,"

Latham and Husseini write.

"However, the data is incomplete; for his book, Constantine Nana correspondedwith the lead investigator in the Port Loko Phase II trial, Dr. Peter Horby of theUniversity of Oxford. Horby told Nana 'he had no information as regards the
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results of the Phase I trial.' To lead a Phase II trial and know nothing about thatproduct's Phase I trial is indeed mysterious and rather strange."

Biosafety Is Lax at Kenema Lab

Latham and Husseini also review the lackadaisical approach to biosafety at the Kenema lab, despite working with extremely dangerous pathogens:

"In the U.S., using live filoviruses requires biosafety level four (BSL-4) facilities,where researchers wear positive pressure 'space suits.' But in Kenema …according to Reuters, biosafety 'measures include goggles, gloves and masks.'The article quoted VHFC member Matt Boisen, a U.S. scientist from Tulane, nowwith Zalgen: 'Certainly we have less safety, less containment, but we do havethe ability to do a lot more in the same amount of time' …Others have corroborated this laxity. In the 2014 outbreak, the earliestemergency responder was the medical non-profit Doctors Without Borders(MSF) who were called in for their extensive Ebola experience. MSF'semergency response coordinator was Anja Wolz. She was highly critical of thebiosafety measures used by Metabiota at Kenema.Having seen how they visited suspected Ebola cases, she told AP: 'I didn't goinside the Metabiota lab … I refused because I had already seen enough.' A CDCoficial, Austin Demby, later sent to investigate, reached similar conclusions.In an email about the Kenema lab he wrote: 'The cross contamination potentialis huge and quite frankly unacceptable.' Thus, there seems to have been apattern at Kenema of lax biosafety procedures both before and during theoutbreak."

Another oddity that doesn't fit the nature of a natural outbreak was the fact that hotspots were broadly spread out. There was no epicenter. Moreover, according to WHO Ebola coordinator Philippe Barboza, Metabiota staffers were "systematically obstructing

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any attempt to improve the existing surveillance system." MSF also complained they got no cooperation from Kenema.

"Given the intentionality imputed by many of these witnesses to the failings inSierra Leone, were they deliberate? If so, were they intended to divert attentionaway from the Kenema lab?"

Latham and Husseini ask.

Genomic Testing

Latham and Husseini then delve into the genomic testing results, which suggest there was a "hidden" or unreported outbreak in Sierra Leone, which only later spread into Guinea. That doesn't prove it came out of a lab in Sierra Leone, however. But unique features in the Makona strain of Ebola that caused the Guinea outbreak suggest the virus may have undergone some form of manipulation. Latham and Husseini explain:

"The Makona strain of Ebola is not a standard or known strain, nor is it similarto any published strain. It is novel, having approximately 400 mutations that arenot found in any previously known Ebola strain. Hence, for the 2014 Ebolaoutbreak to have begun in a lab, the Makona strain must either represent theescape of an unpublished strain, perhaps one collected during fieldwork incentral Africa.Alternatively, Makona could be a radically manipulated derivative of a knownstrain–either through genetic engineering or passaging. A combination of thesetwo possibilities should also be considered.Of these two alternatives, we know that Ebola and other viruses were beingsought from wild animals in the Congo basin at the time as part of USAID'sPREDICT project. The chief actors in this were the Wildlife Conservation Society(WCS) and Metabiota, which, at the time, was at the time a partner of the VHFC…[One] possibility is that Metabiota, or other collectors, used the VHFC lab atKenema as part of a cold chain for the preservation of samples brought fromthe Congo basin …The Kenema lab may also have been used for initial screening or testing of suchsamples. A third possibility is the formal or informal sharing of samples orstrains with VHFC contacts or colleagues at Kenema, perhaps to help in thedevelopment of commercial treatments or diagnostic tools …Given these potentialities it is remarkable to discover that, in July 2014, duringthe epidemic, the VHFC wrote a brief report in which they accused Metabiota ofan activity that would be riskier still.The VHFC accused Metabiota staff at Kenema of culturing cells from Ebolapatients, which they insisted was dangerous and should 'be stoppedimmediately.'Metabiota issued a qualified denial, but the allegation is highly credible sincethe two organisations shared the same site; moreover its implications are verygreat. It suggests, first, that Metabiota had an interest in culturing novel strainsof Ebola, second, that they had the technical capability and the personnelcompetent to do so at Kenema, and third, that they were willing to takeexceptional risks …The allegation therefore raises, in a very concrete way, the question of whatMetabiota might have been doing in Kenema prior to the outbreak … given theresearch interests and the capacities of the VHFC lab in Kenema and itscollaborators, it is a relatively simple matter to theorise how a novel strain ofEbola, like Makona, might have reached Kenema and then spilled over thereduring routine research activities.Interesting too is the dual role of Metabiota. Besides collecting samples fromthe wild, Metabiota was also the company that, at least according to MSF andthe WHO, obstructed or mishandled testing and diagnosis at Kenema and thatSylvia Blyden alleged 'messed up the whole region.'If a research error on the part of Metabiota was the source of the strain (andMetabiota's incompetence has been widely alleged ), or even suspected to be,they would have had a strong incentive to also 'bungle' the identification of earlycases and so obfuscate the origin."

Pathogenic Research Must Be Reined In

While the case for the worst Ebola outbreak in history being the result of a lab leak is still based on circumstantial evidence, that evidence is compelling, and made even more so by the absence of evidence for a zoonotic origin. The same can be said for SARS- CoV-2. Additionally, of all the scientists, companies and organizations involved in this kind of research across the world, how is it that the same short list of names pop up both in the Guinea Ebola case and COVID-19? The take-home message here is that there is no possible way to guarantee containment of viruses in any of these laboratories, not even biosafety level 4 labs. And a pathogen doesn't have to be developed as a bioweapon in order to act like one. If gain-of-function research on lethal viruses is allowed to continue, the whole world will remain at risk, and I don't think its hyperbolic to say gain of function research poses an existential threat to mankind. So far, we've been lucky in that escaped pathogens (suspected or confirmed) have not decimated the global population, but our luck may someday run out.

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