By 2012, it had risen to 1 in 88, then 1 in 68 as of 2016, and now, we're looking at an autism rate of 1 in 44 8-year-olds, although rates vary widely from state to state. In California, where incidence is the highest, 1 in 26 8-year-olds has a diagnosis of autism. Missouri, which has the lowest incidence, has a rate of 1 in 60. According to the1234
U.S. Centers for Disease Control and Prevention, the dramatic uptick is in part due to improved and more comprehensive identification and diagnosis. However, improved diagnosis alone cannot explain this trend. One in 44 children were not autistic in the 1980s, with or without diagnosis. No, something is going on. One or more environmental factors are clearly having a devastating impact on our children.
Mitochondrial Dysfunction in Autism
According to an October 2020 scientific review in the journal Seminars in Pediatric Neurology, “Several lines of evidence implicate mitochondria in the pathophysiology of autism spectrum disorder (ASD).” For years, autism was believed to be due to genetics, but empirical studies have proven genetic predispositions play a very small role.
More recent investigations looking atmitochondrial biomarkers and electron transportchain activity suggest mitochondrial abnormalitiesmay be involved in as many as 80% of cases.
The authors point to “novel abnormalities” in mitochondrial function that have been found in autistic children, and the fact that treatments targeting mitochondrial dysfunction, such as L-carnitine supplementation and a ketogenic diet, have been fruitful. In 2007, approximately 4% of autistic children could be diagnosed with a definite mitochondrial disease. More recent investigations looking at mitochondrial biomarkers and electron transport chain activity suggest mitochondrial abnormalities may be involved in as many as 80% of cases. Biomarkers of mitochondrial dysfunction include elevated levels of: Lactate Pyruvate5
Alanine Creatine kinase Ubiquinone Acyl-carnitines Carnitine (low levels being an indication of dysfunction) As noted by the authors, this is “remarkably interesting” because mitochondria are “very vulnerable to environmental factors.” In other words, something in our environment is triggering mitochondrial dysfunction in an ever-growing percentage of children. The question is what? Children whose autism is rooted in mitochondrial dysfunction will typically have a key set of symptoms that include: Fatigability Gastrointestinal disorders Seizures and/or epilepsy Motor delay and/or ataxia and/or muscle weakness Unusual neurodevelopmental regression, including multiple regressions or regression later than commonly associated with ASD
While classic mitochondrial disease is defined, at least in part, by severe deficits in electron transport chain activity, in children with ASD, mitochondrial dysfunction tends to involve overactivity. According to the authors:
“... we have shown that about one-third of LCLs [lymphoblastoid cell lines]derived from children with ASD repeatedly show elevated respiratoryiou rates,approximately 200% of controls, for respiratory parameters associated withadenosine triphosphate production.6
We have also demonstrated the consequences of elevated respiratory rates;specifically, this subset of ASD LCLs are more sensitive to acute exposure toreactive oxygen species (ROS) such that respiratory rates drop precipitouslywith acute increases in ROS.We hypothesized these changes represent an adaptive response to previousenvironmental exposures, a phenomenon known as mitoplasticity.To support this hypothesis, we demonstrated that elevated respiratory rates canbe induced in LCLs with prolonged exposure (96 hours) to mild ROS, amicroenvironment that simulates the effect of environmental toxicants onmitochondria.Additionally, we have demonstrated that this subset of LCLs respond differentlyto environmental agents associated with ASD, including trichloroacetaldehydehydrate and ethylmercury, and enteric short chain fatty acids propionate andbutyrate, as compared to ASD LCLs which do not demonstrate these highrespiratory rates at baseline.”
Important Nutritional Supplements
Two helpful treatments have already been mentioned: L-carnitine supplementation and ketogenic diets. Studies evaluating ketogenic diets and ASD have found them to be well- tolerated by a majority of children. A review of four studies found 18% of children saw significant improvement on a ketogenic diet, 40% reported moderate improvement and 32% had mild improvement. Only 8% experienced a worsening of their symptoms. In cases where the ASD is caused by mitochondrial dysfunction, however, supplementing specific cofactors become important. The good news is this kind of supplementation is very safe and well tolerated. There's virtually no risk involved, in terms of adverse side effects. Among the most important nutritional cofactors are:78
B vitamins, including niacin (B3), ribofiavin (B2), biotin (B7), thiamine (B1), pyridoxine (B6), pantothenic acid (B5), methylcobalamin (B12), reduced folate (B9) Coenzyme Q10 or the reduced form, ubiquinol L-carnitine or acetyl-L-carnitine Creatine monohydrate Alpha-lipoic acid Vitamin E Vitamin C N-acetyl-L-cysteine (NAC) Zinc
Benefits of L-Carnitine and CoQ10
Of these, L-carnitine has been most widely studied. As explained in this paper:
“Two medium sized (n = 30, 30) double-blind placebo-controlled studies usingL-carnitine treatment (50 mg/kg/d for 3 months and 100 mg/kg/d for 6 months)found that scores on the Childhood Autism Rating Scale (CARS) improved withL-carnitine as compared to placebo with one study finding that greatersymptomatic improvement was correlated with a greater increase in bloodcarnitine levels.A small (n = 10) 8-week open-label trial of L-carnitine used particularly highdoses (up to 400 mg/kg/d in 3 divided doses, maximum of 6000 mg/d) ...Several parental rated measures showed improvements in behavior andhyperactivity before correction for multiple comparisons and improvements inlanguage correlated with post-treatment blood carnitine levels. Children withASD and genetic mutations in the carnitine pathway also appear to response toL-carnitine.”9
CoQ10 has also been evaluated in clinical trials. In one, 50 mg of ubiquinol was given twice a day for three months. Children who attained a CoQ10 blood level above 2.5 umol/L saw improvements in communication, interactions, sleep and food rejection. A three-month-long regimen of L-carnitine, CoQ10 and alpha-lipoic acid also produced encouraging results, improving mitochondrial function and ASD-related behavior. When the children discontinued the cocktail, their behavior worsened again.
Autism and Autoimmunity
Previous research also suggests ASD may have an autoimmunity component. As explained in a 2009 paper titled “Autoimmunity in Autism”:
“Increasing evidence of autoimmune phenomena in individuals with autismcould represent the presence of altered or inappropriate immune responses inthis disorder, and this immune system dysfunction may represent novel targetsfor treatment.Furthermore, in recent studies, antibodies directed against the fetal brain havebeen detected in some mothers of children with autism; these antibodies havethe ability to alter behavioral outcomes in the offspring of animal models.”
Research published in 2013 found that more than 1 in 10 mothers of autistic children had antibodies associated with autoimmunity that adversely reacted with proteins in the brain of the baby, resulting in ASD. The authors point out that any activation of the mother's immune system “might lead to an increased risk of a child with ASD.” In light of the COVID injection campaign, the possibility of autoantibodies playing a role in ASD is extremely troublesome, as autoimmune diseases are a potential side effect. We don't yet really know the extent of which the SARS-CoV-2 spike protein interacts with the human brain, but it's clearly not beneficial. Women, in particular, are suffering neurological dysfunction as a result of the COVID shot. How might the spike protein affect offspring? That's still too early to say, but I10111213
suspect we'll come to find that the effect can be devastating.
Toxic Chemicals Implicated in Autism
Not surprisingly, exposure to toxic chemicals in utero has also been identified as a potentially causative factor. According to the National Academy of Sciences, an estimated 3% of all neurobehavioral disorders in children are caused by toxic exposures. Another 25%, the interaction of toxic exposures and genetic factors is thought to be causative. In 2012, scientists identified 10 chemicals suspected of causing learning disabilities and ASD: Lead Methylmercury Polychlorinated biphenyls (PCBs) Organophosphate pesticides, including glyphosate Organochlorine pesticides Endocrine-disrupting chemicals Automotive exhaust Polycyclic aromatic hydrocarbons (PAHs) Brominated fiame retardants Perfiuorinated compounds Of these, glyphosate is a top suspect for the simple reason that exposure to it is so widespread. Research published in 2019 found women exposed to 11 commonly used pesticides — including glyphosate — during pregnancy have a higher risk of having a child diagnosed with autism. Pregnant women who lived within a 2,000-meter (1.24 miles) radius of a highly-sprayed area were 10% to 16% more likely to have children diagnosed with autism than those who lived farther away. As reported by Time:14151617181920
“When they looked at diagnoses of autism spectrum disorder that also camewith intellectual disabilities, they found on average 30% higher rates amongchildren who were exposed to the pesticides while in utero. Exposure in the firstyear of life increased the risk of autism by up to 50% compared to those notexposed to certain pesticides.”
Glyphosate Is Likely a Key Culprit
Stephanie Seneff, Ph.D., who has spent a large portion of her career studying glyphosate, believes it is a significant cause or contributor to autism. She's shown glyphosate: Disrupts your gut microbiome Impairs peristalsis — a feature that is exceedingly common in children with autism Inhibits bile acid release by impairing gallbladder contraction — Many autistic children have very pale stool, suggestive of low bile acid levels Impairs digestive enzymes — Many autistic children also have undigested particles in their stool, which suggests a lack of digestive enzymes. And, indeed, glyphosate affects your digestive enzymes, particularly trypsin, pepsin and lipase
The Roles of GI Infiammation and Maternal Gut Bacteria
Another potential trigger is maternal gut infiammation. Research published in early December 2021 found that when pregnant mice were challenged with immune activation, it changed their gut microbiota. This altered microbiota in turn primed the offspring for intestinal infiammation that resulted in neurodevelopmental disorders. MIT News reported the findings, noting:
“Infection during pregnancy with elevated levels of the cytokine IL-17a mayyield microbiome alterations that prime offspring for aberrant immuneresponses ...212223
When a mother experiences an infection during pregnancy and her immunesystem produces elevated levels of the molecule Interleukin-17a (IL-17a), thiscan not only alter brain development in her fetus, but also alter her microbiomesuch that after birth the newborn's immune system can become primed forfuture infiammatory attacks.In four studies beginning in 2016, study co-senior authors Gloria Choi of MITand Jun Huhof Harvard University traced how elevated IL-17a during pregnancyacts on neural receptors in a specific region of the fetal brain to alter circuitdevelopment, leading to autism-like behavioral symptoms in mouse models.Their new research ... shows how IL-17a can act to also alter the trajectory ofimmune system development. ‘We've shown that IL-17a acting on the fetal braincan induce autism-like behavioral phenotypes such as social deficits,' says Choi...‘Now we are showing that the same IL-17a in mothers, through changes in themicrobiome community, produces co-morbid symptoms such as a primedimmune system.'The researchers caution that the study findings are yet to be confirmed inhumans, but that they do offer a hint that central nervous and immune systemproblems in individuals with autism-spectrum disorders share an environmentaldriver: maternal infection during pregnancy.”
Here, the COVID-19 pandemic may end up worsening an already terrible trend, as the infection is associated with elevated IL-17a. IL-17a is a key molecule in both the innate and adaptive immunity that helps mobilize your immune system response during early infection. It's been singled out as being involved in the thrombotic and vascular mechanisms of COVID-19 specifically. One October 2021 study suggested IL-17a acts as a silent amplifier of the COVID-19 immune response, resulting in some of the worst side effects associated with the infection. While pregnant women are universally instructed to get the COVID shot to242526
protect themselves from the infection, there's every reason to suspect the injection may cause far more harm than the infection itself. If you get COVID while pregnant, you may or may not have a serious case of it, but if you take the shot, you have a 100% chance of suffering the effects of it, which for many include dramatically elevated levels of infiammation. From my perspective, getting the COVID jab because you fear what COVID-19 might do to you and/or your baby is actually irrational, as your risk of adverse effects from the shot is exponentially higher than your risk of severe COVID-19 infection.
Autism Is a Multifactorial Condition
A number of other culprits could also be named, such as retroviruses (which the COVID shots can reactivate) and electromagnetic field (EMF) exposure. According to Judy Mikovits, Ph.D., a retrovirus family known as xenotropic murine leukemia virus-related viruses (XMRV) may play a causal role in autism. Disturbingly, one source for XMRVs is contaminated childhood vaccines. Mikovits details the history of this in her book, “Plague: One Scientist's Intrepid Search for the Truth About Human Retroviruses and Chronic Fatigue Syndrome (ME/CFS), Autism and Other Disease.” In previous interviews with me, Mikovits has also expressed concern that the COVID shots may activate latent XMRV infection. If it does, we could expect the autism rate to explode at an even more exponential rate than we're seeing already. I predict the COVID shots will be found to contribute to autism in a number of different ways. But even in the absence of these injections, it's clear that environmental toxicities are wreaking havoc with our children's health. There's no single answer to this problem. Since many different toxins can contribute, preventing autism must include the elimination of most toxic exposures.27
Top suspects include childhood vaccines, the 10 chemicals listed earlier (glyphosate in particular), autoimmune antibodies, gut infiammation, retroviruses and EMF exposure. To this list, I would also add the COVID gene transfer injections, as they can be a source of severe infiammation and autoimmunity, and have been shown to have a direct adverse impact on neurology.
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