Here, I interview three vitamin D experts about the importance of vitamin D for improving your immune function and resistance to viral infections of all kinds, including COVID-19. Bruce Hollis, Ph.D., with the Medical University of South Carolina, has researched vitamin D since the late 1970s. His research associate at the Medical University of South Carolina is Dr. Carol Wagner, who is a neonatologist and has been researching vitamin D since 2000. Carole Baggerly is the director and founder of GrassrootsHealth Nutrient Research Institute, a nonprofit public health research organization dedicated to moving public health messages regarding vitamin D from research into practice. Baggerly received our Game Changer Award in 2018. She started her work in vitamin D after treatment for breast cancer in 2005.
Vitamin D Levels Correlate With Disease Severity
GrassrootsHealth conducted a review of an observational study involving 212 patients in Southeast Asia who had COVID-19, identifying a correlation between vitamin D levels and disease severity. Those with the mildest disease had the highest vitamin D levels, and vice versa. Of the 212 people, 49 had mild disease; 59 had ordinary disease; 56 were severe and 48 were critical. In the initial study group of 212 patients (see Table 1 below), 55 had normal vitamin D levels, which was defined as greater than 30 ng/ml; 80 had insuficient levels of 21 to 29 ng/ml and 77 had deficient levels of less than 20 ng/ml. Now, it's worth noting that the "optimal" vitamin D level in that study was set at 30 nanograms per milliliter (30 ng/mL), which may actually be suboptimal. According to the research done by GrassrootsHealth, 40 ng/mL is the lower edge of optimal, with 60 ng/mL to 80 ng/mL being ideal for health and disease prevention. Despite that, the benefit of having a vitamin D level above 30 ng/mL was clear.
Vitamin D Levels Correlate With Mortality Risk
A second study looked at the data from 780 hospital patients in Indonesia. The same vitamin D level cutoffs were used in this study: below 20 ng/mL; between 20 ng/mL and 30 ng/mL; and above 30 ng/mL. After adjusting for confounding factors, those with a vitamin D level between 20 ng/mL and 30 ng/mL had a sevenfold higher risk of death than those with a level above 30 ng/mL. Having a level below 20 ng/mL was associated with a 12 times higher risk of death. As noted by Hollis, "That's really strong data."
It's Your Vitamin D Blood Level That Matters, Not the Dose
Now, many vitamin D studies conclude that vitamin D supplementation has little or no effect on any given health problem or condition. But there's a very simple reason for this: Virtually every one of these studies use the same dosage or dosages for everyone, and do not measure participants' blood levels. This is a crucial mistake, as it's really the blood level that needs to get over a particular threshold, and the dosage required to get there can vary widely. Another problem is the fact that most studies use far too low a dosage. If the dosage is too low, you cannot get your blood level into the protective range, and thus it will appear as though vitamin D is useless. A third factor that can infiuence the outcome of vitamin D studies is the interaction between vitamin D and other nutrients. Competing deficiencies can affect a particular sub cohort or population, thereby obfuscating results. A fourth factor is how you define deficiency — using a "word" versus a serum level. For the GrassrootsHealth Scientists' Panel of 48 researchers, the consensus is that minimum serum level should be 40 ng/ml (100 nmol/L). Wagner explains:
"If you do a PubMed search, you see literally thousands of articles. You see thisreally rich basic science information that's been accumulating in the last twodecades, that strongly supports vitamin D's role in immunity.But then, when randomized control trials are done, there are some that suggestvitamin D is effective and others say no. It's been a contentious issue and I'msure Bruce and Carole
will agree with me that doing nutrients studiesis not the same as doing a pharma study where … they start with zero as theirbaseline.[When it comes to] vitamin D [levels], everybody is different. And so, using abiomarker, which is what we use in our studies, total circulating 25(OH)D is amuch better indicator."
"In nutrient studies with vitamin D, it's always been the dosage — how muchyou're going to give — with no concern about what the attained blood levelswould be.In our studies, of course, we always measure blood levels. Those studies thatCarol
and I carried out in pregnancy (in 2003), they were monitored bythe FDA. We had to get an investigational drug number (IDN) to run thesestudies, and it was unheard of to have to do that …In the end, we proved the [dosage] we [gave] — 4,000 units — was totallyharmless as far as dosing went. But it's still a fight … We have yet to see oneadverse event due to vitamin D in any of the studies that Carol
and Ihave carried out, not a single one …"
Laws Need Updating
Unfortunately, with labeling laws the way they are, it's very dificult to get this point across. As noted by Baggerly:
the FDA … for the ability to be able to print on the
any vitamin D supplement that '
may help have a healthypregnancy and
birth outcomes.' What we were told in that meeting bythe FDA person was, 'According to what dose?'We explained repeatedly that it wasn't a dose, it was a serum level, and the FDAperson in charge said, 'By law, we can only accept recommendations based ondose, and if you can't provide us with a dose, we cannot accept anyrecommendation.' So, the laws are out of date, to say the least."
Skin Color Impacts Your Vitamin D Deficiency Risk
The color of your skin has correlations to your vitamin D level, and we're also seeing racial disparities in COVID-19. As noted by Hollis, in Detroit, Michigan, where African- Americans account for 14% of the population, they accounted for 40% of COVID-19 deaths.
"It was even worse in Sweden where the Somali population is less than 1%, andthey
40% of the deaths,"
"In Britain, of the 24 healthcare physicians who have died, 23 were people of color. It was so bad that theypulled those people off the front lines … the physicians and the nurses."
Vitamin D deficiency likely plays a role in this racial disparity, although nutrition, obesity and diabetes rates also contribute to immune dysfunction. It's important for people with darker skin to realize that the more melanin you have, the more sun exposure you require to make suficient amounts of vitamin D. According to Hollis, it's physiologically impossible for a dark-skinned individual in the United States, unless they're in Southern Florida or Hawaii, to get optimal vitamin D from typical sun exposure.
Daily Supplementation May Strengthen Lung Tissue
If for whatever reason you cannot get regular sun exposure, then vitamin D supplementation is advisable. Ideally, you'll want to take it daily, opposed to taking a1
large bolus dose once a week or once a month. As noted by Hollis, studies have consistently shown only daily supplementation were effective.
"When they looked at bolus supplementation, the effect on respiratory infectiondisappeared,"
"Taking a bolus dose every other week or once a month,every three months, that was not effective at controlling respiratory infections.So, we prefer daily [supplementation]."
"The vitamin D component produced in the skin as a result of sun exposure is atone stage what we take as a supplement, the D3, and that then is metabolizedinto 25(OH)D, which is what we're measuring, for the most part.The D3 and even the 25(OH)D have been considered in times past … as notbeing active … In recent studies, and we really are talking relatively recent, theD3 itself seems to be active in helping keep the epithelia strong
[to prevent endothelial leakage]
Vitamin D3's ability to strengthen the endothelial structure of the lungs may be one way in which vitamin D helps protect against COVID-19. "COVID-19 attacks the lungs … and vitamin D in this model showed to stabilize that," Hollis says.
Vitamin D Strengthens and Regulates Immune Function
Vitamin D also has a clear effect on your innate immune system, which is your first line of defense against bacteria and viruses, as well as your adaptive immune system, which involves your T regulatory helper and suppressor cells, and natural killer cells. All of these need to be in balance, Wagner explains. If an imbalance occurs, you can end up with a cytokine storm. According to Wagner, vitamin D is very effective for regulating and balancing adaptive immunity. One example demonstrating the elegance of this system is pregnancy. Wagner explains:
"You go from a very active immune system where you have, as the egg isfertilized, an invasion into the uterine wall. You have to allow for that, [and] it's avery pro-infiammatory state. Then, in order to allow fetal growth, you have tohave quiescence of that
You see shifts in the T cell populations, the phenotypes, as well as in themonocyte macrophage population, their activity. And then, at the time ofdelivery, you shift back to a proinfiammatory state
go into labor andhave expulsion of the fetus and the placenta. So, it's a tremendously elegantprocess.We know that when it's deranged, we get such conditions as preeclampsia. Youget a vasculitis throughout the body and it can lead to death of both the motherand the fetus, and you have a cytokine storm during that. So COVID-19 is notlike a foreign alien; it's utilizing the very immune system that we have in ourbody and it makes sense.Even though this particular virus is new, it's incorporating systems within ourbody that are ancient and that includes a very ancient pre-pro hormone, which isvitamin D.So, it makes sense to me, as a physician and as a scientist, that thoseindividuals who have balance in their bodies, and in this case vitamin D balance,they're going to do better than if they had deficiency
they can'tmobilize those
cells. Those cells are going to be dysfunctional."
Research has also demonstrated that pregnant women with optimal vitamin D levels significantly reduce their child's risk of developing Type 1 diabetes, which is an autoimmune disorder. As noted by Baggerly:
"We're working with the Diabetes Research Center to see whether, even after thechild is born, as long as they don't have full-blown type 1 diabetes, what can wedo to help stop it? And it turns out that the combination of vitamin D andomega-3 really matters."
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