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Biology

A collection of 1010 articles

Map plasticity following noise exposure in rat auditory cortex: Implications for disentangling neural correlates of tinnitus and hyperacusis

Both tinnitus and hyperacusis, likely triggered by hearing loss, can be attributed to maladaptive plasticity in auditory perception.

Engineered probiotic cocktail with two cascade metabolic Escherichia coli for the treatment of hyperlysinemia

Engineering probiotics have emerged as a potential strategy for the treatment of metabolic diseases.

Network analysis combined with experimental assessment to explore the therapeutic mechanisms of new shenqi pills formula targeting mitochondria on senile diabetes mellitus

The objective of this study was to investigate the mechanisms of action of SQP in the treatment of SDM and make an experimental assessment.Methods: Network analysis is used to evaluate target pathways related to SQP and SDM. Mitochondrial-related genes were obtained and intersected with the common target genes of

The Role of Mitochondrial Disorders in Neurodevelopmental Disorders and Psychiatric/Behavioral Conditions

Mitochondrial diseases are known inborn errors affecting energy metabolism and are as common as chronic diseases such as diabetes, affecting approximately 1 in 5,000 people.

Pharmacologic inhibition of Dipeptidyl peptidase 1 (Cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells

Recently developed small molecule inhibitors of the lysosomal protease dipeptidyl peptidase 1 (DPP1), also known as cathepsin C (CatC), can suppress suppurative inflammation in vivo by blocking the processing of zymogenic (pro-) forms of the neutrophil serine proteases (NSPs), including neutrophil elastase, proteinase 3, and cathepsin G. However, DPP1 also

Expression and clinical significance of interleukin-6 pathway in cholangiocarcinoma

Background: Cholangiocarcinoma (CCA) is a typical inflammation-induced malignancy, and elevated serum interleukin-6 (IL-6) levels have been reported to be linked to the onset and progression of CCA.

Effect of blueberry intervention on endothelial function: A systematic review and meta-analysis

Endothelial dysfunction indicates blood vessel injury and is a risk factor for cardiovascular diseases.

Chronic Pain Due to Mitochondrial Dysfunction, Niacinamide Can Treat It

About 21% of U.S.

Mother’s Day Poetry: Las Tradiciones

To honor ourselves, we must first learn to honor our mothers, grandmothers, and every ancestor before them.We do not realize how much we accept from them until they are gone.

Genome-wide identification of bZIP transcription factors and their expression analysis in Platycodon grandiflorus under abiotic stress

The Basic Leucine Zipper (bZIP) transcription factors (TFs) family is among of the largest and most diverse gene families found in plant species, and members of the bZIP TFs family perform important functions in plant developmental processes and stress response. To date, bZIP genes in Platycodon grandiflorus have not been

Class I TCP in fruit development: much more than growth

Fruit development can be viewed as the succession of three main steps consisting of the fruit initiation, growth and ripening.

Identification of male-fertility gene AsaNRF1 and molecular marker development in cultivated garlic (Allium sativum L.)

Garlic cultivars are predominantly characterized by their sterility and reliance on asexual reproduction, which have traditionally prevented the use of hybrid breeding for cultivar improvement in garlic. Our investigation has revealed a notable exception in the garlic line G398, which demonstrates the ability to produce fertile pollen. Notably, at the

LexA, an SOS response repressor, activates TGase synthesis in Streptomyces mobaraensis

Transglutaminase (EC 2.3.2.13, TGase), an enzyme that catalyzes the formation of covalent cross-links between protein or peptide molecules, plays a critical role in commercial food processing, medicine, and textiles. TGase from Streptomyces is the sole commercial enzyme preparation for cross-linking proteins. In this study, we revealed that

How Ultraprocessed Foods Are Slowly Killing Us

Consumption of ultraprocessed foods in the U.S.

Dissolving Illusions About Vaccine Safety

In this interview, Dr.