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John Foo

Autoimmune uveitis attenuated in diabetic mice through imbalance of Th1/Th17 differentiation via suppression of AP-1 signaling pathway in Th cells

Inflammation is involved in the pathogenesis of diabetes, however the impact of diabetes on organ-specific autoimmune diseases remains unexplored.Experimental autoimmune uveoretinitis (EAU) is a widely accepted animal model of human endogenous uveitis. In this study, we investigated the effects of diabetic conditions on the development of EAU using a

Fascinating Research on Vitamin A From 1925

My colleague Pam Schoenfeld, MS, recently put me onto an eye-opening article on vitamin A.

Only YOU can stop euthanasia

Plasma fatty acids and attention deficit hyperactivity disorder: a Mendelian randomization investigation

Background: Attention deficit hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder of childhood, and pathogenesis is not fully understood.

A nomogram for predicting cerebral white matter lesions in elderly men

Objective: This study aimed to develop a nomogram tool to predict cerebral white matter lesions (WMLs) in elderly men.

The research progress of perioperative non-pharmacological interventions on postoperative cognitive dysfunction: a narrative review

Postoperative cognitive dysfunction (POCD) is a common neurological complication in elderly patients after surgery and general anesthesia.

Genomic prediction for sugarcane diseases including hybrid Bayesian-machine learning approaches

Sugarcane smut and Pachymetra root rots are two serious diseases of sugarcane, with susceptible infected crops losing over 30% of yield.

Long-Term Oral Administration of Huaier Granules Improves Survival Outcomes in Hepatocellular Carcinoma Patients Within Milan Criteria following Microwave Ablation: A Propensity Score Matching and Stabilized Inverse Probability Weighting Analysis

Objective: This study aimed to elucidate the therapeutic effects of Huaier granules on hepatocellular carcinoma (HCC) within the Milan criteria in patients who underwent microwave ablation (MWA). Materials and Methods: A total of 228 patients were included, with 97 in the Huaier group and 131 in the control group. We

What We Don’t Seem to Care About

When I say “we” in the title of this article, I don’t mean us shrews.

Epigenetically active chromatin in neonatal iWAT reveals GABPα as a potential regulator of beige adipogenesis

Background: Thermogenic beige adipocytes, which dissipate energy as heat, are found in neonates and adults.

Coal mining environment causes adverse effects on workers

Background: The objective of this study is to study the adverse effects of coal mining environment on workers to discover early effective biomarkers.

Latent class analysis and longitudinal development trajectory study of psychological distress in patients with stroke: a study protocol

Background: Psychological distress affects the treatment and rehabilitation of patients with stroke, affects their long-term functional exercise and quality of life, and increases the risk of stroke recurrence and even death. This is a multi-dimensional and multi-level mental health problem and a dynamic process variable that shows a dynamic development

The Interactive Effect between Economic Uncertainty and Life History Strategy on Corrupt Intentions: A Life History Theory Approach

Why do some people show more corruption when facing uncertain environment?The present study aimed to give a plausible answer from an evolutionary perspective: this might be rooted in people's different life history strategies (slow vs. fast). The present study measured the participants' corrupt intentions by a hypothetical scenario and

What are the implications if WHO succeeds in imposing its IHR amendments on us?

To understand the impact the World Health Organisation’s (“WHO’s”) proposed International Health Regulations (“IHR”) amendments will have on every person on Earth, we have to get to grips with what totalitarian rule is – because should the amendments proposed by WHO be accepted next month, the people of the