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Matthew Medinsky

LP340, a novel histone deacetylase inhibitor, decreases liver injury and fibrosis in mice: role of oxidative stress and microRNA-23a

Effective therapy for liver fibrosis is lacking.Here, we examined whether LP340, the lead candidate of a new-generation of hydrazide-based HDAC1,2,3 inhibitors (HDACi), decreases liver fibrosis.

The bispecific B7H3xCD3 antibody CC-3 induces T cell immunity against bone and soft tissue sarcomas

Sarcomas are rare and heterogeneous malignancies that are difficult to treat.Approximately 50% of patients diagnosed with sarcoma develop metastatic disease with so far very limited treatment options.

Ultra rapid lispro improves postprandial glucose control versus lispro in combination with basal insulin: A study based on CGM in type 2 diabetes in China

Aim: To evaluate the efficacy and safety of URLi (ultra rapid lispro insulin) compared to insulin lispro as bolus insulin with basal insulin using CGM in the individuals with type 2 diabetes(T2D) in China.Methods:This was a double-blind, randomized, parallel, prospective, phase 3 study.Subjects with uncontrolled T2D

Tobacco consumption and quality of life among teachers: a bidirectional problem

Objective: This study aimed to assess a bidirectional relationship between tobacco consumption and quality of life among Chilean teachers.

Idarucizumab in dabigatran-treated patients with acute stroke: a review and clinical update

Idarucizumab is an antibody fragment specific for immediate reversal of dabigatran anticoagulation effects.

Why Do We Yawn?

Editor's Note: This article is a reprint.

Effect of needle-free injection on psychological insulin resistance and insulin dosage in patients with type 2 diabetes

Background and Objective: Psychological insulin resistance (PIR), which refers to the reluctance of diabetic patients to use insulin, is a frequently encountered clinical issue.

Anti-inflammatory and/or immunomodulatory activities of Uncaria tomentosa (cat's claw) extracts: a systematic review and meta-analysis of in vivo studies

Background: Uncaria tomentosa (Willd.ex Schult.) DC.(Rubiaceae), is traditionally used by Amazonian indigenous groups to treat inflammatory diseases.

A streamlined workflow for a fast and cost-effective count of tyndallized probiotics using flow cytometry

The use of dead probiotics and their cellular metabolites seems to exhibit immunomodulatory and anti-inflammatory properties, providing protection against pathogens.

Ancient Formula May Be the Ultimate Antibiotic Solution

Editor's Note: This article is a reprint.

Causal relationship between genetic proxies for calcium channel blockers and the risk of depression: A drug-target Mendelian randomization study

Background: Calcium channel blockers (CCBs) are widely used in the clinical management of hypertension.

Computer Vision Syndrome and Ergonomic Risk Factors Among Workers of the Commercial Bank of Ethiopia in Addis Ababa, Ethiopia: An Institutional-Based Cross-Sectional Study

Background: Computer vision syndrome (CVS) is the most pressing public health concern that affects vision, and reduces quality of life and productivity, particularly in developing countries.Most of the previous studies conducted in Ethiopia focus on the knowledge and personal risk factors of bank workers. Moreover, ergonomic workstation design was

Gingiva squamous-cell carcinoma in a non-smoking patient with occupational exposure to solvent siphoning using mouth: case report and literature review

Background: While overall head and neck cancer incidence decreases due to reduced tobacco and alcohol consumption, the incidence of HPV negative oral cavity squamous cell carcinoma (SCC) is raising in several industrialised countries, especially in non-smoking and non-drinking patients.Case presentation: We document a case of gingiva SCC in a

A qualitative investigation of the Montgomery–Åsberg depression rating scale: discrepancies in rater perceptions and data trends in remote assessments of rapid-acting antidepressants in treatment resistant depression

Introduction: Despite the development of many successful pharmaceutical interventions, a significant subset of patients experience treatment-resistant depression (TRD).

Changes of serum cortisol during pregnancy and labor initiation: an onsite cross-sectional study

Background: Increased maternal cortisol secretion has been observed during pregnancy and labor.