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Matthew Medinsky

Celiac Disease and Attention-Deficit/Hyperactivity Disorder: A Bidirectional Mendelian Randomization Analysis

Recent observational research suggests a potential link between celiac disease (CeD) and an increased incidence of attention-deficit/hyperactivity disorder (ADHD).

Pharmacologic inhibition of Dipeptidyl peptidase 1 (Cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells

Recently developed small molecule inhibitors of the lysosomal protease dipeptidyl peptidase 1 (DPP1), also known as cathepsin C (CatC), can suppress suppurative inflammation in vivo by blocking the processing of zymogenic (pro-) forms of the neutrophil serine proteases (NSPs), including neutrophil elastase, proteinase 3, and cathepsin G. However, DPP1 also

Effect of blueberry intervention on endothelial function: A systematic review and meta-analysis

Endothelial dysfunction indicates blood vessel injury and is a risk factor for cardiovascular diseases.

Chronic Pain Due to Mitochondrial Dysfunction, Niacinamide Can Treat It

About 21% of U.S.

Class I TCP in fruit development: much more than growth

Fruit development can be viewed as the succession of three main steps consisting of the fruit initiation, growth and ripening.

How Ultraprocessed Foods Are Slowly Killing Us

Consumption of ultraprocessed foods in the U.S.

Dissolving Illusions About Vaccine Safety

In this interview, Dr.

Prognostic Models for Mucinous and Non-specific Adeno Cholangiocarcinoma: A Population-based Retrospective Study

Background: Clinically, the diagnosis and treatment of cholangiocarcinoma are generally different according to the location of occurrence, and the studies rarely consider the differences between different pathological types. Cholangiocarcinomas in large-and middle-sized intrahepatic bile ducts are mostly mucinous, while in small sized bile duct are not; mucinous extrahepatic cholangiocarcinomas are

They’re lying, we know they’re lying and they know we know they’re lying

“We know they are lying.

Placental co-transcriptional activator Vestigial-like 1 (VGLL1) drives tumorigenesis via increasing transcription of proliferation and invasion genes

Vestigial-like 1 (VGLL1) is a co-transcriptional activator that binds to TEA domain-containing transcription factors (TEADs).

An optimized method for IgE-mediated degranulation of human lung mast cells

Background: Mast cells are critically involved in IgE-mediated diseases, e.g., allergies and asthma.

‘Ozempic Face’ — A Troubling Side Effect of Weight Loss Drugs

Prescriptions for weight loss medications have skyrocketed in recent years.

State-and Frequency-Dependence in Autonomic Rebalance mediated by Intradermal Auricular Electroacupuncture Stimulation

Background: Vagus nerve stimulation (VNS) improves diseases such as refractory epilepsy and treatment-resistant depression, likely by rebalancing the autonomic nervous system (ANS).

Dr. Mike Yeadon: Anything with mRNA written on it is designed to be harmful

In a discussion with Geoff Buys Cars last month, Dr.

Long-acting prescriptions and therapy for HIV-1 from market launch to the present in Germany (May 2021 to December 2023)

In Europe, the combination of cabotegravir (CAB) with rilpivirine (RPV) has been approved as a dual injection long-acting (LA) therapy for the treatment of human immunodeficiency virus type 1 (HIV-1) infections in adults since December 2020. Studies have shown that between 36% and 61% of people living with HIV (PLWHIV)