You can quote several words to match them as a full term:
"some text to search"
otherwise, the single words will be understood as distinct search terms.
ANY of the entered words would match

DTI-ALPS index decreased in Patients with Type 2 Diabetes Mellitus

Backgrounds: Type 2 diabetes mellitus (T2DM) has become a significant global public health issue, characterized by a rising prevalence and associated deficits across multiple organ systems.

DTI-ALPS index decreased in Patients with Type 2 Diabetes Mellitus

Our study aims to utilize the DTI-ALPS technique to assess the change of ALPS index in T2DM patients, and to explore whether such changes are correlated with cognition level and diffusion parameters. Methods: The study involved 41 patients with T2DM(mean age, 60.49±8.88 years) and 27 healthy controls(mean age, 58.00±7.63 years). All subjects underwent MRI examination, cognitive assessment, and laboratory tests. Tract-based spatial statistics (TBSS) was used to evaluate white matter changes. GLM was performed to check the DTI-ALPS index difference between T2DM and HC groups. Spearman correlation analysis and partial correlation analysis was used to analyze the correlation between the DTI-ALPS index, diffusion properties, cognitive scales. Results: The results show that the ALPS index was lower in T2DM patients. MoCA score was significantly correlated with the ALPS index. Patients with T2DM had a significant increase in both mean diffusivity (MD) and radial diffusivity (RD) and decrease in fractional anisotropy (FA) in these clusters compared to the HC group. Conclusions: The results suggest that the ALPS index is decreased in T2DM patients and associates with cognitive level..

Read the full article at the original website


Subscribe to The Article Feed

Don’t miss out on the latest articles. Sign up now to get access to the library of members-only articles.