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From ... in Health Lifestyle Biology —

Magnesium and K2 Optimize Your Vitamin D Supplementation

This article was previously published June 15, 2020, and has been updated with new information.

Magnesium and K2 Optimize Your Vitamin D Supplementation

Optimizing your vitamin D level is ideally done through sensible sun exposure. However, many simply are unable to obtain suficient levels from the sun alone and need

supplemental vitamin D. In this case, nutritional synergies become an important factor. According to research by GrassrootsHealth, "combined intake of both supplemental magnesium and vitamin K2 has a greater effect on vitamin D levels than either individually," and "those taking both supplemental magnesium and vitamin K2 have a higher vitamin D level for any given vitamin D intake amount than those taking either supplemental magnesium or vitamin K2 or neither."

You Need 2.5 Times More D if Not Taking Magnesium and K2

GrassrootsHealth is a nonprofit, independent public health research institute that has been conducting large-scale population-based nutrient research since 2007. While a significant focus is on vitamin D, the organization has also branched into other nutrients. Its D*action project includes a global cohort of over 10,000 self-subscribed individuals who anonymously provide information about their supplement use and overall health status. GrassrootsHealth research shows blood levels in the range of 40 nanograms per milliliter to 60 ng/ml (100 nanomoles per liter to 150 nmol/L) are safe, effective and will lower overall disease incidence and health care costs. That said, other nutrients have been shown to work synergistically with vitamin D, and being deficient in them can significantly infiuence your vitamin D status as well. Importantly, data from nearly 3,000 individuals reveal you need 244% more oral vitamin D if you're not also taking magnesium and vitamin K2. As reported by GrassrootsHealth:

"… 244% more supplemental vitamin D was needed for 50% of the population toachieve 40 ng/ml (100 nmol/L) for those not taking supplemental magnesiumor vitamin K2 compared to those who usually took both supplementalmagnesium and vitamin K2."
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What this means in practical terms is that if you take all three supplements in combination, you need far less oral vitamin D in order to achieve a healthy vitamin D level.

How Magnesium Affects Vitamin D

I've previously written about the importance of taking vitamin K2 to avoid complications associated with excessive calcification in your arteries when you're taking high-dose supplemental vitamin D. In fact, relative vitamin K2 deficiency is typically what produces symptoms of "vitamin D toxicity." That said, magnesium is also a crucial part of the equation, as it is a component necessary for the activation of vitamin D. Without suficient amounts of it, your body cannot properly utilize the vitamin D you're taking. This actually helps explain why many need rather high doses of vitamin D to optimize their levels — it could be that they simply have insuficient amounts of magnesium in their system to activate the vitamin D. As noted by Mohammed Razzaque, professor of pathology at Lake Erie College of Osteopathic Medicine in Pennsylvania:

"People are taking vitamin D supplements but don't realize how it getsmetabolized. Without magnesium, vitamin D is not really useful. By consumingan optimal amount of magnesium, one may be able to lower the risks of vitaminD deficiency, and reduce the dependency on vitamin D supplements."

According to a scientific review published in 2018, as many as 50% of Americans taking vitamin D supplements may not get significant benefit as the vitamin D simply gets stored in its inactive form, and the reason for this is because they have insuficient magnesium levels. Research published in 2013 also highlighted this issue, concluding that higher magnesium intake helps reduce your risk of vitamin D deficiency by activating more of it. As noted by the authors:

"High intake of total, dietary or supplemental magnesium was independentlyassociated with significantly reduced risks of vitamin D deficiency andinsuficiency respectively.Intake of magnesium significantly interacted with intake of vitamin D in relationto risk of both vitamin D deficiency and insuficiency … Our preliminary findingsindicate it is possible that magnesium intake alone or its interaction withvitamin D intake may contribute to vitamin D status."

Similarly, GrassrootsHealth has found you need 146% more vitamin D to achieve a blood level of 40 ng/ml (100 nmol/L) if you do not take supplemental magnesium,

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compared to taking your vitamin D with at least 400 mg of magnesium per day. The interplay between magnesium and vitamin D isn't a one-way street, though. It goes both ways. Interestingly, while vitamin D improves magnesium absorption, taking large doses of vitamin D can also deplete magnesium. Again, the reason for that is because magnesium is required in the conversion of vitamin D into its active form.

Vitamins D, B12 and Magnesium May Affect COVID-19 Outcomes

While vitamin D and magnesium are important for overall health year-round, they may be of particular importance right now, as we're still dealing with the COVID-19 pandemic in

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many areas of the world, and a second wave is expected in the fall. According to preliminary research, that is still undergoing peer review, older COVID- 19 patients given a combination of vitamin D, magnesium and vitamin B12 fared significantly better than those who did not receive the supplements:

"Between 15 January and 15 April 2020, 43 consecutive COVID-19 patientsaged ≥50 were identified. 17 patients received DMB [vitamin D, magnesium andB12] and 26 patients did not. Baseline demographic characteristics between thetwo groups were similar.Significantly fewer DMB patients than controls required initiation of oxygentherapy subsequently throughout their hospitalization (17.6% vs 61.5%). DMBexposure was associated with odds ratios of 0.13 … and 0.15 … for oxygentherapy need and/or intensive care support on univariate and multivariateanalyses respectively.Conclusions: DMB combination in older COVID-19 patients was associated witha significant reduction in proportion of patients with clinical deteriorationrequiring oxygen support and/or intensive care support. This study supportsfurther larger randomized control trials to ascertain the full benefit of DMB inameliorating COVID-19 severity."

Signs of Vitamin D Deficiency

The idea that vitamin D might play a role in COVID-19 severity makes sense considering its importance in infections, including viral infections, in general. Vitamin D helps regulate your immune function, and deficiency is associated with more frequent infections and infiammation-related illnesses of all types. Other common signs and symptoms of vitamin D deficiency include: Muscle weakness and fatigue Bone and joint pain, as well as fractures

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Depression Impaired cognition and headaches Slow wound healing

To improve your immune function and lower yourrisk of viral infections, you'll want to raise yourvitamin D to a level between 60 ng/mL and 80 ng/mLby fall. In Europe, the measurements you're lookingfor are 150 nmol/L and 200 nmol/L. Optimizing yourvitamin D is particularly important if you are older orhave darker skin.

Long-term deficiency can also contribute to more chronic health problems, including rickets, cardiovascular disease and autoimmune disease. Risk factors for vitamin D deficiency include: Rarely spending time outdoors and/or always wearing sunscreen Having darker skin Being over the age of 50 Obesity Having gastrointestinal problems

Optimize Your Vitamin D Before Fall

Aside from age and comorbidities such as diabetes, obesity and heart disease, vitamin D deficiency has also been identified as an underlying factor that significantly impacts COVID-19 severity and mortality. I discuss this in "Vitamin D Is Directly Correlated to COVID-19 Outcome."

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The following graph is from a May 18, 2020, letter to the Federal Chancellor of Germany, Angela Merkel, from retired biochemist Bernd Glauner and Lorenz Borsche, in which they highlight studies showing a clear correlation between COVID-19 mortality and vitamin D levels. It's important to note that, like most coronaviruses, SARS-CoV-2 cases can reemerge in the fall when temperatures and humidity levels drop, thereby increasing the virus' transmissibility. To improve your immune function and lower your risk of viral infections, you'll want to raise your vitamin D to a level between 60 ng/mL and 80 ng/mL before fall. In Europe, the measurements you're looking for are 150 nmol/L and 200 nmol/L. Optimizing your vitamin D is particularly important if you are older or have darker skin. One of the easiest and most cost-effective ways of measuring your vitamin D level is to participate in the GrassrootsHealth's personalized nutrition project, which includes a

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  • Vitamin D*calculator

vitamin D testing kit, either alone or in combination with the omega-3 test. This is done in the convenience of your home. To make sure your vitamin D level and immune system function are optimized, follow these three steps: 1. First, measure your vitamin D level — Once you know what your blood level is, you can assess the dose needed to maintain or improve your level. The easiest way to raise your level is by getting regular, safe sun exposure, but if you're very dark- skinned, you may need to spend about 1.5 hours a day in the sun to have any noticeable effect. Those with very light skin may need only 15 minutes a day, which is far easier to achieve. Still, they too will typically struggle to maintain ideal levels during the winter. So, depending on your situation, you may need to use an oral vitamin D3 supplement. The next question then becomes, how much do you need? 2. Assess your individualized vitamin D dosage — To do that, you can either use the chart below, or use GrassrootsHealth's Vitamin D*calculator . To convert ng/mL into the European measurement (nmol/L), simply multiply the ng/mL measurement by 2.5. To calculate how much vitamin D you may be getting from regular sun exposure in addition to your supplemental intake, consider using the DMinder app.

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3. Retest in three to six months — Lastly, you'll need to remeasure your vitamin D level in three to six months, to evaluate how your sun exposure and/or supplement dose is working for you. Not only will optimizing your vitamin D be an important strategy for you and your family, but it would be really helpful to start thinking about your community as well. If you can, speak to pastors in churches with large congregations of people of color and help them start a program getting their congregation on vitamin D, and if you have a family member or know anyone who is in an assisted living facility, meet with the director of the program and encourage them to get everyone tested or at least start them on vitamin D. We really need an army of people to make a difference and build up the immune resiliency of the population as we fight COVID and other respiratory diseases. It's never too late to begin. For extra information on the value of vitamin D in lowering your risk for COVID-19, please see my paper in the journal Nutrients, which highlights evidence that people and physicians can use or recommend vitamin D supplements to prevent or treat COVID- 19 in light of their safety and wide therapeutic window.

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