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Dan Simmer

Macrophage polarization in rheumatoid arthritis: signaling pathways, metabolic reprogramming, and crosstalk with synovial fibroblasts

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction.

Exploration of the Mechanism of Traditional Chinese Medicine for Anxiety and Depression in Patients with Diarrheal Irritable Bowel Syndrome Based on Network Pharmacology and Meta-analysis

The efficacy of Chinese herbal medicine (CHM) in managing irritable bowel syndrome with diarrhea (IBS-D) accompanied by anxiety and depression remains uncertain.

Exploration of the Mechanism of Traditional Chinese Medicine for Anxiety and Depression in Patients with Diarrheal Irritable Bowel Syndrome Based on Network Pharmacology and Meta-analysis

The efficacy of Chinese herbal medicine (CHM) in managing irritable bowel syndrome with diarrhea (IBS-D) accompanied by anxiety and depression remains uncertain.

Association between human blood metabolites and cerebral cortex architecture: evidence from a Mendelian randomization study

Background: Dysregulation of circulating metabolites may affect brain function and cognition, associated with alterations in the cerebral cortex architecture.However, the exact cause remains unclear.

Mendelian randomization and single-cell expression analyses identify the causal relationship between depression and chronic rhinosinusitis

The causative relationship between chronic rhinosinusitis (CRS) and depression remains unclear.

Deciphering Glycosylation-Driven Prognostic Insights and therapeutic Prospects in Glioblastoma through a Comprehensive Regulatory Model

The oncogenesis and development of glioblastoma multiforme have been linked to glycosylation modifications, which are common post-translational protein modifications.

Exploring the evocative qualities of masks visual imagery and their associations with adversity and trauma

Studies suggest a relationship between the emotional evocativeness of visual imagery and viewer responses, however, there is limited understanding of these associations, especially as they relate to viewers' personal experiences of adversities. In this exploratory study, we examined the relationship between the visual content of mask images and viewers' responses.

MSG and Free Glutamate: Lurking Everywhere

Some time ago, on a trip to British Columbia, I ate in a local restaurant.

Alfalfa supplementation timing changes the rumen archaeal and fungal community composition and colonization in pre-weaning lambs

The establishment of the rumen microbiota plays an important role in the rumen development.However, little is known about the effects of alfalfa supplementation time on rumen microbiota establishment.

Randomized controlled trial of an Acceptance and Commitment Therapy and compassion-based group intervention for persons with inflammatory bowel disease: the LIFEwithIBD intervention

Objectives: This study tested the acceptability and efficacy of an Acceptance and Commitment Therapy and compassion-based intervention (LIFEwithIBD) in people with IBD through a two-arm RCT.

Peer assumption: an illusory consensus hidden in the criminal responsibility of juvenile offender—evidence from psychology

Introduction: There is a consensus hidden in the criminal legislation of many countries that the criminal responsibility capacity of juvenile offenders is not significantly different from that of their peers. The purpose of this paper was to test this hypothesis. The research objects of this paper were 187 juvenile offenders

Shock Study Finds E-Cigarettes May Raise Risk of Heart Failure

It's a myth that electronic cigarettes (e-cigarettes) are safer for your health than regular cigarettes.

What Is Aloe Vera Good For?

Editor's Note: This article is a reprint.

The treatment process of a giant phyllodes tumor of the breast: a case report and review of the literature

Giant phyllodes tumors are rare fibroepithelial tumors that are usually larger than 10 cm in diameter, have rapid tumor growth, and are easily recurrent.

Does the level of burnout differ between occupational groups in Lithuania?

Background: The strain on workers of the healthcare system and education sector increased psychological distress and burnout.