'We're All Plastic People Now': A Groundbreaking Documentary A plastic straw, a bottle of water, a plastic bag from the grocery — these single-use plastics seem so innocuous that people barely give them a second thought before tossing them out.
Microplastics and geoengineering: A danger to all life on Earth A study published last week found significant concentrations of microplastics in the testicular tissue of both humans and dogs. The findings add to growing concern about microplastics’ possible effect on human reproductive health. Researchers from the University of New Mexico (“UNM”) published their paper in the journal Toxicological Sciences which
Combination of Bacillus tequilensis with difenoconazole to control pear black spot and the related synergistic mechanism Background: Pear black spot (PBS) is caused by Alternaria alternata and causes severe damage worldwide.
The Role of Mitochondrial Disorders in Neurodevelopmental Disorders and Psychiatric/Behavioral Conditions Mitochondrial diseases are known inborn errors affecting energy metabolism and are as common as chronic diseases such as diabetes, affecting approximately 1 in 5,000 people.
Celiac Disease and Attention-Deficit/Hyperactivity Disorder: A Bidirectional Mendelian Randomization Analysis Recent observational research suggests a potential link between celiac disease (CeD) and an increased incidence of attention-deficit/hyperactivity disorder (ADHD).
Pharmacologic inhibition of Dipeptidyl peptidase 1 (Cathepsin C) does not block in vitro granzyme-mediated target cell killing by CD8 T or NK cells Recently developed small molecule inhibitors of the lysosomal protease dipeptidyl peptidase 1 (DPP1), also known as cathepsin C (CatC), can suppress suppurative inflammation in vivo by blocking the processing of zymogenic (pro-) forms of the neutrophil serine proteases (NSPs), including neutrophil elastase, proteinase 3, and cathepsin G. However, DPP1 also
Effect of blueberry intervention on endothelial function: A systematic review and meta-analysis Endothelial dysfunction indicates blood vessel injury and is a risk factor for cardiovascular diseases.
Class I TCP in fruit development: much more than growth Fruit development can be viewed as the succession of three main steps consisting of the fruit initiation, growth and ripening.
Prognostic Models for Mucinous and Non-specific Adeno Cholangiocarcinoma: A Population-based Retrospective Study Background: Clinically, the diagnosis and treatment of cholangiocarcinoma are generally different according to the location of occurrence, and the studies rarely consider the differences between different pathological types. Cholangiocarcinomas in large-and middle-sized intrahepatic bile ducts are mostly mucinous, while in small sized bile duct are not; mucinous extrahepatic cholangiocarcinomas are
Placental co-transcriptional activator Vestigial-like 1 (VGLL1) drives tumorigenesis via increasing transcription of proliferation and invasion genes Vestigial-like 1 (VGLL1) is a co-transcriptional activator that binds to TEA domain-containing transcription factors (TEADs).
An optimized method for IgE-mediated degranulation of human lung mast cells Background: Mast cells are critically involved in IgE-mediated diseases, e.g., allergies and asthma.