Subscribe

Matthew Medinsky

Move for Life an intervention for inactive adults aged 50 years and older: A cluster randomised feasibility trial

Background: Move for Life (MFL) is a theory-informed intervention that was developed to augment established physical activity (PA) programmes and enable inactive adults aged 50 years and older to more active. This study examined the feasibility of MFL and sought to provide evidence of its potential for improving PA and

Prognostic Stratification of Glioblastoma Patients by Unsupervised Clustering of Morphology Patterns on Whole Slide Images Furthering Our Disease Understanding

Glioblastoma (GBM) is a highly aggressive malignant tumor of the central nervous system that displays varying molecular and morphological profiles, leading to challenging prognostic assessments.

Autism and ADHD Linked to Disturbed Gut Flora Very Early in Life

The makeup of gut fiora at birth and during the first year of life may play a key role in the development of neurodevelopmental disorders, including autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), communication disorders and intellectual disability. Worldwide, 3.4 billion people suffer from health conditions that

LP340, a novel histone deacetylase inhibitor, decreases liver injury and fibrosis in mice: role of oxidative stress and microRNA-23a

Effective therapy for liver fibrosis is lacking.Here, we examined whether LP340, the lead candidate of a new-generation of hydrazide-based HDAC1,2,3 inhibitors (HDACi), decreases liver fibrosis.

The bispecific B7H3xCD3 antibody CC-3 induces T cell immunity against bone and soft tissue sarcomas

Sarcomas are rare and heterogeneous malignancies that are difficult to treat.Approximately 50% of patients diagnosed with sarcoma develop metastatic disease with so far very limited treatment options.

Ultra rapid lispro improves postprandial glucose control versus lispro in combination with basal insulin: A study based on CGM in type 2 diabetes in China

Aim: To evaluate the efficacy and safety of URLi (ultra rapid lispro insulin) compared to insulin lispro as bolus insulin with basal insulin using CGM in the individuals with type 2 diabetes(T2D) in China.Methods:This was a double-blind, randomized, parallel, prospective, phase 3 study.Subjects with uncontrolled T2D

Tobacco consumption and quality of life among teachers: a bidirectional problem

Objective: This study aimed to assess a bidirectional relationship between tobacco consumption and quality of life among Chilean teachers.

Idarucizumab in dabigatran-treated patients with acute stroke: a review and clinical update

Idarucizumab is an antibody fragment specific for immediate reversal of dabigatran anticoagulation effects.

Why Do We Yawn?

Editor's Note: This article is a reprint.

Effect of needle-free injection on psychological insulin resistance and insulin dosage in patients with type 2 diabetes

Background and Objective: Psychological insulin resistance (PIR), which refers to the reluctance of diabetic patients to use insulin, is a frequently encountered clinical issue.

Anti-inflammatory and/or immunomodulatory activities of Uncaria tomentosa (cat's claw) extracts: a systematic review and meta-analysis of in vivo studies

Background: Uncaria tomentosa (Willd.ex Schult.) DC.(Rubiaceae), is traditionally used by Amazonian indigenous groups to treat inflammatory diseases.

A streamlined workflow for a fast and cost-effective count of tyndallized probiotics using flow cytometry

The use of dead probiotics and their cellular metabolites seems to exhibit immunomodulatory and anti-inflammatory properties, providing protection against pathogens.

Ancient Formula May Be the Ultimate Antibiotic Solution

Editor's Note: This article is a reprint.

Causal relationship between genetic proxies for calcium channel blockers and the risk of depression: A drug-target Mendelian randomization study

Background: Calcium channel blockers (CCBs) are widely used in the clinical management of hypertension.

Computer Vision Syndrome and Ergonomic Risk Factors Among Workers of the Commercial Bank of Ethiopia in Addis Ababa, Ethiopia: An Institutional-Based Cross-Sectional Study

Background: Computer vision syndrome (CVS) is the most pressing public health concern that affects vision, and reduces quality of life and productivity, particularly in developing countries.Most of the previous studies conducted in Ethiopia focus on the knowledge and personal risk factors of bank workers. Moreover, ergonomic workstation design was